【摘要】 【目的】采用文献分析的方式探讨特发性膜性肾病(idiopaphic membranous nephropathy,IMN)登记研究的国际现状,并对IMN登记研究在中医药研究领域的应用前景进行探讨。【方法】采用计算机检索医学文献数据库和临床试验注册中心,对纳入文献的关键信息如文献发表时间、研究开展地区、承担单位、研究设计、研究目的、样本量等进行梳理,并对数据进行总结分析。【结果】共纳入13篇文献,其中英文文献12篇,意大利文文献1篇。IMN登记研究设计以回顾性队列研究为主,研究内容涵盖IMN患病率、无创性诊断、治疗方案及疗效评估、远期预后和并发症等。【结论】目前IMN登记研究数量较少,研究设计的提升空间较大。未来期望能建立中医药治疗IMN的患者登记平台,以期可规范采集和多角度分析IMN中医临床信息,开展包含证候等中医因素的IMN预后研究,探索中医用药规律和安全性等。更多还原

【Abstract】 Objective To explore the international research status of the registry study of idiopathic membranous nephropathy(IMN)by literature analysis method, and to explore the application of IMN registry study in the traditional Chinese medicine(TCM)research. Methods The medical literature databases and clinical trial registry platforms were reviewed by computer retrieval. The information such as the publication time, research sites,institutions, study design, research purpose, and sample size was collected and analysed. Results A total of13 articles were included, 12 articles were in English and one was in Italian. Most of the included articles belonged to retrospective cohorts. These studies focused on the prevalence, non-invasive diagnosis, treatment regimens and the evaluation of the efficacy,long-term prognosis and the complications of IMN. Conclusion Up to now,there have been a few reports about IMN registry study,and the increase of the quality of research design of the IMN registry study is needed. In the future,it is expected to establish a registry platform for the treatment of IMN with traditional Chinese medicine,so as to collect the standard TCM information of IMN treated by Chinese medicine and to make the multiple perspective analysis,to carry out long-term prognosis research associated with the syndrome types of TCM,and to explore the medication rule and safety of Chinese medicine therapy.更多还原