【摘要】 目的探究血清补体及尿蛋白肌酐比(ACR)水平与妊娠并发系统性红斑狼疮(SLE)患者流产及早产的相关性。方法选择2018年3月—2020年8月本院收治的妊娠并发SLE患者120例纳入并发组,选择同期于本院进行孕检的健康孕妇104名纳入对照组。观察并记录两组孕妇血清补体C3、C4含量及ACR水平变化;分析血清补体及ACR水平与妊娠并发SLE患者流产及早产的相关性;采用Logistic回归分析影响妊娠并发SLE患者发生流产及早产的相关因素。结果并发组血清补体C3、C4含量显著低于对照组,孕周显著短于对照组(P<0.05),ACR水平、流产及早产发生率均显著高于对照组(P<0.05);流产及早产组孕妇血清补体C3、C4含量显著低于非流产及早产组(P<0.05),ACR水平显著高于非流产及早产组(P<0.05);Logistic回归分析结果显示,血清补体C3、C4降低、ACR水平升高均为影响妊娠并发SLE患者发生流产及早产的独立危险因素(P<0.05)。结论妊娠并发SLE患者血清补体C3、C4含量显著降低,ACR水平显著升高,且与患者不良妊娠结局中流产及早产的发生有关。更多还原

【Abstract】 Objective To explore the correlation between serum complement and urinary albumin-to-creatinine ratio(ACR)levels and abortion and premature delivery in pregnant women with systemic lupus erythematosus(SLE).Methods A total of 120 cases of pregnant women complicated with SLE those were admitted to our hospital from March 2018 to August 2020 were selected as the concurrent group, and 104 healthy pregnant women who underwent pregnancy examination in our hospital during the same period were selected as the control group.The contents of serum complement C3,C4 and level of ACR were observed and recorded; the correlation of serum complement and ACR levels with miscarriage and preterm delivery in pregnant women with SLE was analyzed; Logistic regression analysis was used to analyze the related factors led to abortion and premature delivery in pregnant women with SLE.Results The levels of serum complement C3 and C4 in the concurrent group were significantly lower than those in the control group, and the gestational week was significantly shorter than that in the control group(P<0.05),while the level of ACR,the incidences of abortion and premature delivery in the concurrent group were significantly higher than those in the control group(P<0.05).The levels of serum complement C3 and C4 in abortion and premature delivery group were significantly lower than those in non abortion and premature delivery group(P<0.05),and the level of ACR was significantly higher than that in non abortion and premature delivery group(P<0.05).Logistic regression analysis showed that the decreases of serum complement C3 and C4 and the increase of ACR level were the independent risk factors of abortion and premature delivery in pregnant women with SLE(P<0.05).Conclusions The contents of serum complement C3 and C4 in pregnant women with SLE is significantly decreased, and the level of ACR is significantly increased.And they are related to the occurrence of abortion and premature delivery in patients with adverse pregnancy outcomes.更多还原