【摘要】 根据拼合原理,将1-氯芳基-(3,4)-二氯苯基引入吡唑环设计成新颖结构的1-氯芳基-(3,4)-二氯苯基-4-(1,2,4)-三唑基吡唑化合物,并研究其合成工艺。寻求制备具有杀菌活性的化合物5-{[(3-甲基-5-氯-1-(3,4)-二氯苯基)]-吡唑基]-(1,2,4)-三唑-[3,4]-1-硫-(3,4)-二氮-5-[(3,5)-二氯-4-甲基)]苯基-6-[(3-氟-4-硝基)苯基]}环己烷。以3-甲基-(3,4)-二氯苯基-5-氯-5-吡唑啉酮和三氯氧磷为起始原料,经过氯甲酰化、氧化、酯化、肼解、取代、环合、缩合、亲核加成反应制得目标化合物5-{[(3-甲基-5-氯-1-(3,4)-二氯苯基)-吡唑基]-(1,2,4)-三唑-[3,4]-1-硫-(3,4)-二氮-5-[(3,5)-二氯-4-(甲基)苯基]-6-[(3-氟-4-硝基)-苯基]}环己烷。在优化的条件下,目标化合物纯度为99.1%。该工艺简单经济,条件温和,合成工艺减少了溶剂的用量和废物排放量。更多还原

【Abstract】 According to the principle of combination,1-aryl chloride-( 3,4)-dichlorophenyl was introduced into pyrazole ring to obtain 1-aryl chloride-( 3,4)-dichlorophenyl-4-( 1,2,4)-triazole pyrazole compounds with novel structures. The synthesis process was studied to look for the compounds with fungicide activities. The target compounds can be obtained through chloroformylation, oxidation, esterification, hydrazinolysis, replace, cyclization, condensation and electeophilic addition reaction. 3-methyl-( 3,4)-dichloro-1--phenyl)-5-chlorination-5-pyrazolone and phosphorus oxychloride were used as raw materials. Under optimized conditions,the purity of the target compounds can reach up to 99. 1%. The process is simple,economic and mild,reducing the amount of solvent and waste discharge.更多还原