【摘要】 目的探讨术前外周血淋巴细胞与单核细胞比值(LMR)、人甘露糖结合凝集素相关丝氨酸蛋白酶2(MASP-2)水平在Ⅲ期结肠癌患者预后评估中的价值。方法选取进行结肠癌根治术的100例Ⅲ期结肠癌患者为本次研究对象。以患者手术时间为起点,对患者进行至少3年的随访,随访至2020年1月,以患者死亡为失效事件,记录患者生存时间。收集并整理患者临床资料,将可能影响患者预后的变量(性别、年龄、肿瘤分化程度、肿瘤TNM分期、肿瘤最大直径、肿瘤部位、LMR值、MASP-2水平)等纳入Ⅲ期结肠癌预后的单因素及多因素分析中。结果肿瘤直径可以显著影响Ⅲ期结肠癌患者生存状况(HR=2.286)。血清LMR值、MASP-2含量也是显著影响Ⅲ期结肠癌患者生存状况的独立影响因素(HR=0.642、0.598)。结论术前外周血LMR值、MASP-2含量检测有助于对Ⅲ期结肠癌患者预后情况的预测。更多还原

【Abstract】 Objective To investigate the value of LMR and MASP-2 levels in the prognosis assessment of stage Ⅲ colon cancer patients.Methods A total of 100 patients with stage Ⅲ colon cancer who underwent radical resection of colon cancer in our hospital from January 2012 to January 2015 were selected as the subjects of this study. The patients were followed up for at least three years starting from the time of surgery. The patient’s death was regarded as a failure event and the patient’s survival time was recorded. The clinical data of the patients were collected and collated, and the variables that might affect the prognosis of the patients(gender, age, degree of tumor differentiation, TNM stage, maximum tumor diameter, tumor site, LMR value, MASP-2 level)were included in the univariate and multivariate analysis of the prognosis of stage Ⅲ colon cancer.Results Tumor diameter significantly influenced the survival status of patients with stage Ⅲ colon cancer(Hr=2.286). Serum LMR value and MASP-2 content were also independent factors that significantly affected the survival status of patients with stage Ⅲ colon cancer(HR=0.642,0.598). Conclusion Preoperative detection of peripheral blood LMR value and MASP-2 content are helpful to predict the prognosis of stage Ⅲ colon cancer patients.更多还原