【摘要】 目的:分析多囊卵巢综合征(PCOS)患者血清和肽素与胰岛素抵抗(IR)的关系。方法:100例PCOS作为病例组,选取80名同期体检的育龄期女性作为对照组,均于卵泡早期采集空腹静脉血,检测空腹胰岛素(FINS)、空腹血糖(FPG)和肽素及性激素[促卵泡刺激素(FSH)、睾酮(T)、黄体生成素(LH)]水平,计算胰岛素抵抗指数(HOMA-IR);并常规体格检查,测定身高、体重、腰围、臀围,计算身体质量指数(BMI)及腰臀比(WHR)。按IR情况分为IR组(HOMA-IR≥2.69)与非IR组(HOMA-IR<2.69),分析PCOS血清各参数与HOMA-IR的关系。结果:病例组WHR、BMI、T、LH、FPG、FINS、HOMA-IR、和肽素均高于对照组(P<0.05);PCOS中的IR组WHR、T、LH、PFG、FINS及和肽素水平均高于非IR组(P<0.05);PCOS患者WHR、BMI、FPG、FINS、HOMA-IR与血和肽素水平呈正相关(P<0.05);多因素Logistic回归分析结果显示,高和肽素、BMI和WHR是PCOS患者发生HOMA-IR的影响因素(P<0.05)。结论:PCOS患者血清和肽素呈高水平,合并IR的PCOS患者和肽素异常表达更明显;和肽素可能为参与PCOS人群发生IR的关键因子。更多还原

【Abstract】 Objective:To analyze relationship between serum, copeptin levels and insulin resistance(IR) in patients with polycystic ovary syndrome(PCOS).Methods:100 patients with PCOS were enrolled as case group.80 women during childbearing age who underwent physical examination in the same period were enrolled as control group.Fasting venous blood was collected in early follicles.The levels of fasting insulin(FINS),fasting blood glucose(FPG),copeptin and sex hormones [follicle stimulating hormone(FSH),testosterone(T),luteinizing hormone(LH)] were detected.The homeostasis model assessment-insulin resistance index(HOMA-IR) was calculated.Routine physical examination was conducted to determine height, weight, waist circumference and hip circumference.Body mass index(BMI) and waist-hip ratio(WHR) were calculated.According to different IR,they were divided into IR group(HOMA-IR not less than 2.69) and non-IR group(HOMA-IR less than 2.69).The relationship between PCOS serum parameters and HOMA-IR was analyzed.Results:WHR,BMI,T,LH,FPG,FINS,HOMA-IR and copeptin in case group were higher than those in control group(P<0.05).The levels of WHR,T,LH,PFG,FINS and copeptin in IR group were higher than those in non-IR group(P<0.05).WHR,BMI,FPG,FINS and HOMA-IR were positively correlated with levels of serrum and copeptin(P<0.05).Multivariate Logisitic regression analysis showed that high copeptin, obesity and WHR were the influencing factor of HOMA-IR in PCOS patients(P<0.05).Conclusion:The levels of serum and copeptin are abnormally high in PCOS patients.The abnormal expression of copeptin is more significant in PCOS patients with HOMA-IR.Copeptin may be a key factor involved in occurrence of PCOS IR.更多还原