【摘要】 目的:探究酮替芬联合孟鲁司特对咳嗽变异性哮喘(CVA)患儿肺功能及炎症因子的影响。方法:62例CVA患儿分为对照组和观察组,每组各31例。对照组治疗予以孟鲁司特,观察组予以酮替芬联合孟鲁司特。比较两组患儿临床疗效及治疗前后咳嗽症状评分、肺功能[1s用力呼气容积(FEV1)、呼气峰值流速(PEF)、 FEV1占用力肺活量百分比(FEV1/PVC)]、炎症因子[白细胞介素-5(IL-5)、肿瘤坏死因子-α(TNF-α)、血清淀粉样蛋白A(SAA)、骨膜蛋白]水平,并观察两组患儿不良反应。结果:观察组患儿临床总有效率高于对照组(P<0.05)。治疗后,与对照组相比,观察组日间和夜间咳嗽症状积分更低,FEV1、PEF、FEV1/PVC上调程度及血清IL-5、TNF-α、SAA、骨膜蛋白水平下调程度均更大(P<0.05)。两组药物不良反应总发生率比较,差异无统计学意义(P>0.05)。结论:酮替芬联合孟鲁司特对咳嗽变异性哮喘患儿临床疗效良好,可有效改善咳嗽症状,增强肺功能,减轻炎症反应,且安全性好。更多还原

【Abstract】 Objective:To explore the effects of ketotifen combined with montelukast on pulmonary function and inflammatory factors in children with cough variant asthma.Methods:A total of 62 children with cough variant asthma were randomly divided into control group(n=31) and observation group(n=31).The control group was treated with montelukast and the observation group was treated with ketotifen combined with montelukast.The clinical efficacy,cough symptom score,pulmonary function [1 s forced expiratory volume(FEV1),peak expiratory flow rate(PEF),percentage of 1 s forced expiratory volume to forced vital capacity(FEV1/PVC)],inflammatory factors [interleukin-5(IL-5),tumor necrosis factor-α(TNF-α),serum amyloid A(SAA),periosteal protein] were compared between the two groups before and after treatment,and the adverse reactions of the two groups were observed.Results:The total clinical effective rate of the observation group was significantly higher than that of the control group(P<0.05).After treatment,the scores of daytime and nocturnal cough symptoms in the observation group were lower than those in the control group,and the up-regulated levels of FEV1,PEF,FEV1/PVC and the levels of serum IL-5,TNF-α,SAA and periosteal protein in the observation group were significantly lower than those in the control group(P<0.05).There was no significant difference in the total incidence of adverse drug reactions between the two groups(P>0.05).Conclusion:Ketotifen combined with montelukast is effective in the treatment of children with cough variant asthma,which can effectively improve cough symptoms,enhance lung function,and reduce inflammatory reaction,with higher safety.更多还原