【摘要】 铅是一种重金属污染物,对人和动物健康损害极大。众多研究发现铅毒性作用的重要靶器官是骨骼,即铅进入机体后会蓄积在骨骼内,极易导致骨质疏松症。在临床上,铅对骨骼的危害主要通过一些骨代谢生化指标进行评估,如PINP、OPG、β-CTX、CT等。近年来多项研究发现骨代谢生化指标可以反映骨代谢状态以及骨转换率,这对于骨质疏松症的鉴别诊断具有重要意义。综述了铅对骨代谢生化指标影响的研究进展,以期为探究铅对骨代谢影响的分子机制提供参考。更多还原

【Abstract】 Lead is a heavy metal pollutant and is extremely harmful to human and animal health. Many studies have found that bone is the important target organ of lead toxicity. Lead accumulates in bone after absorption in body which results in osteoporosis. In clinic, the damages of lead to bone are mainly evaluated by some biochemical indexes of bone metabolism such as PINP, OPG, β-CTX and CT. In recent years, studies have shown that biochemical indexes of bone metabolism revealed the bone metabolism state and bone conversion rate, which is of great significance for the differential diagnosis of osteoporosis. In this paper, the research advances on the effects of lead on biochemical indexes of bone metabolism are reviewed, in hoping to provide references for investigation of the molecular mechanism underlining the impacts of lead on bone metabolism.更多还原