【摘要】 目的:探讨青少年甲状腺体积与代谢指标的相关性。方法:选取江苏省常州市1 097例12～15岁青少年学生(男55.6%),进行体格检查、生化检测以及甲状腺超声检查。对比研究正常、超重、肥胖组青少年甲状腺体积大小,分析代谢综合征组分数量与甲状腺体积之间的关系,并进一步研究代谢相关指标与甲状腺体积的相关性。结果:男性超重组和肥胖组甲状腺体积与正常组相比差异均有统计学意义(P<0.001);女性肥胖组甲状腺体积与正常组相比差异有统计学意义(P<0.001)。不同代谢综合征组分数量组间相比,甲状腺体积大小的差异有统计学意义(F=10.64,P<0.01)。多元回归分析显示,与甲状腺体积相关的指标为性别(β=0.607,95%CI:0.406～0.808,P<0.01)、年龄(β=0.200,95%CI:0.107～0.294,P<0.01)、收缩压(β=0.010,95%CI:0.002～0.018,P=0.014)、腰围(β=0.029,95%CI:0.015～0.042,P<0.01)和腰围身高比(β=3.317,95%CI:1.661～4.973,P<0.01)。结论:超重、肥胖及代谢综合征组分数量与青少年甲状腺体积相关。更多还原

【Abstract】 Objective:To explore the association of metabolic parameters and thyroid volume in Chinese adolescents. Methods:A total of 1 097 middle school students aged between 12～15 years old(55.6% males)were enrolled. All the participants underwent physical examination,biochemical test,and thyroid gland ultrasonography. The thyroid volume of normal,overweight and obese group was compared. The association between the number of metabolic syndrome components and thyroid volume was analyzed to study the association between metabolic parameters and thyroid volume. Results:In male,the differences of thyroid volume between normal and overweight group(P<0.01)or between normal and obesity group(P<0.01)were significant. In female,the difference of thyroid volume between normal and obesity group(P<0.01)was significant. Among groups with different number of metabolic syndrome components,the difference of thyroid volume was significantly different(F=10.64,P<0.01). According to multiple regression model,parameters with significant association with thyroid volume were gender(β=0.607,95%CI:0.406～0.808,P<0.01),age(β=0.200,95%CI:0.107～0.294,P<0.01),systolic blood pressure(β=0.010,95%CI:0.002～0.018,P=0.014),waist circumference(β=0.029,95%CI:0.015～0.042,P<0.01)and the waist-to-height ratio(β=3.317,95%CI:1.661～4.973,P<0.01). Conclusion:Overweight,obesity and number of components of metabolic syndrome are significantly associated with the volume of thyroid glands in adolescents.更多还原