【摘要】 研究某品牌保健酒的急性毒性和亚急性毒性,为评价其食用安全性提供试验依据。对某品牌保健酒进行大鼠、小鼠急性经口毒性试验和大鼠30 d喂养试验。试验结果表明,大鼠、小鼠急性经口MTD值>15000 mg/kg·BW,属无毒级;3个剂量组雌、雄大鼠的每周体重、每周进食量、每周食物利用率、总食物利用率、脏体比值、血液学指标及末期血生化指标检测结果与15%vol基酒对照组比较,各项指标均无显著性差异(P>0.05);除动物自发病变外,受试物高剂量组未引起动物中毒性损伤。某品牌保健酒在本试验条件下未显示有急性毒性或亚急性毒性。更多还原

【Abstract】 In this paper we evaluated the acute toxicity and subacute toxicity of a healthcare liqueur, so as to provide experimental basis for the evaluation of its safety. The acute oral toxicity test on mice and rats and the 30-day feeding test on rats were performed.The results showed that, the MTD for mice and rats was more than 15000 mg/kg·BW(non-toxic). In the 30-day feeding test, there was no significant difference in weight increase, food intake, food utilization, organ coefficient, blood routine examination and blood biochemistry indexes between treatment group and 15 %vol base liquor control group(P>0.05). Except for pathologic changes, high-dose-group rats had no toxic injury on organs. Accordingly, the healthcare liqueur showed no acute toxicity or subacute toxicity in the tests.更多还原