【摘要】 为解决表没食子儿茶素没食子酸酯（Epigallocatechin gallate,EGCG）在实际应用中稳定性差、易被氧化的问题。基于"熵增驱动凝胶形成"理论,制备以魔芋葡甘聚糖多糖（Konjac glucomannan,KGM）微凝胶为载体的KGM-EGCG轭合物体系,通过计算机模拟和数学模型分析维系体系稳定的作用力,通过扫描电子显微镜（SEM）和红外光谱（FT-IR）,对KGM-EGCG的拓扑网络的结构和性质进行系统研究,并揭示体系抗氧化稳定性可能的机理。结果表明,KGM-EGCG结合过程中,随着EGCG浓度增大,其对疏水作用的贡献会增大,氢键连接数量会增多,分子间作用力增强,存在明显的拓扑现象。通过熵增驱动形成的KGM-EGCG体系的热稳定性较好,且具有较好的O₂-自由基和DPPH自由基清除率。KGM-EGCG微凝胶不仅具有较好的抗氧化性而且控释效果好。更多还原

【Abstract】 To solve the problems of poor stability and easy oxidation of Epigallocatechin gallate（EGCG） in practical application. In this study,the KGM-EGCG yoke system was prepared using Konjac Glucomannan（KGM） microgel as carrier based on the theory of“entropy-driven gel formation”. The forces maintaining the stability of the system were analyzed by molecular simulation and mathematical model. The structure and properties of KGM-EGCG topological heterogeneous network were systematically studied by scanning electron microscopy（SEM） and infrared spectroscopy（FT-IR）,and the possible mechanism of antioxidant stability of the system was revealed. The results showed that during the KGM-EGCG binding process,as the concentration of EGCG increases,its contribution to hydrophobic interaction,its number of hydrogen bond connections and the intermolecular forces will all increase, resulting in obvious topological isomerism. The KGM-EGCG system formed by topological isomerism driver has better thermal stability,O₂-·scavenging force and DPPH·scavenging force. KGM-EGCG microgel has not only good antioxidant activity but also good controlled release effect.更多还原