【摘要】 瘢痕疙瘩(Keloid)是一种发病机制不明的皮肤纤维增生性疾病,伴有极高的复发率。近年来,通过对干细胞特征表面抗原鉴定,发现瘢痕疙瘩中可能存在间充质干细胞(Mesenchymal-like stem cell)和造血干细胞(Hematopoietic stem cells)。后续的研究进一步发现各种刺激因素作用下,例如:炎症反应、外界张力作用下,发生上皮-间充质改变,这就影响了正常的干细胞所处的一个由间充质细胞、细胞外基质、血管和炎性细胞等共同构成的微环境(Niche),从而形成一种独特的病理微环境来促进瘢痕疙瘩干细胞的增殖。外源性干细胞用于瘢痕疙瘩的临床治疗尚处于实验阶段,对瘢痕疙瘩相关干细胞的深入研究,将为探索瘢痕疙瘩发病机制和临床治疗提供一个新方向。更多还原

【Abstract】 Keloid is a skin fibroproliferative disease of unknown pathogenesis,with an extremely high recurrence rate.In recent years,with antigen identification of surface of stem cell features,mesenchymal-like stem cells and hematopoietic stem cells that may be present in keloid have been discovered.Subsequent research further found:under the effects of various stimulating factors,for example the effects of inflammatory response and external tension,epithelial-mesenchymal will change.This effects the niche in which the normal stem cells are located,a niche composed of mesenchymal-like cells,extracellular matrix,blood vessels,inflammatory cells,etc.Thus forming a unique pathological niche to promote the proliferation of keloid stem cells.The clinical treatment of exogenous stem cells for keloid is still in experimental stage.Deep research on keloid-related stem cells will provide a new direction for exploring the pathogenesis and clinical treatment of keloid.更多还原