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伽马刀联合化疗对局部淋巴结转移性食管鳞状细胞癌患者的影响

Effect of gamma knife combined with chemotherapy on tumor markers and immunological indexes in patients with esophageal squamous cell carcinoma with local lymph node metastasis

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【作者】 王皓颖赵一电梁垲王晓敏

【Author】 WANG Hao-ying;Department of Radiotherapy Anyang Tumor Hospital;

【通讯作者】 赵一电;

【机构】 安阳市肿瘤医院放疗科

【摘要】 目的探讨伽马刀联合化疗运用于局部淋巴结转移性食管鳞状细胞癌患者后,对其血液中肿瘤标记物及免疫学指标的影响。方法选取在安阳市肿瘤医院放疗科治疗的局部淋巴结转移性食管鳞状细胞癌患者130例(纳入研究116例),按照随机数字表法分为对照组和观察组,各58例,对照组行伽马刀放射治疗,观察组在对照组基础上联合紫杉醇/顺铂(Paclitaxel/Cisplatin, TP)化疗。比较两组患者治疗前及治疗1个月后的临床疗效、血液中肿瘤标记物、细胞及体液免疫学指标的差异。结果 (1)两组患者临床疗效方面比较,差异无统计学意义(χ~2=2.157,P=0.142)。(2)两组患者治疗前后细胞角蛋白19片段抗原(cytokeratin 19 fragment antigen 21-1,CYFRA21-1)、鳞状上皮细胞癌抗原(Squamous cell carcinoma antigen, SCC)、癌胚抗原(carcinoembryonic antigen, CEA)水平差值具有统计学差异(P<0.05)。(3)观察组CD3、CD8、CD56/CD3、CD16/CD3明显高于对照组,CD4明显低于对照组(P<0.05)。(4)两组患者治疗前后IgG、IgM、IgA、C3、C4水平差值具有统计学差异(P<0.05)。结论伽马刀联合化疗治疗局部淋巴结转移性食管鳞状细胞癌患者,可有效降低CYFRA21-1、SCC、CEA水平,改善机体的细胞免疫及体液免疫功能,提高患者自身免疫力。

【Abstract】 Objective To investigate the effect of gamma knife combined with chemotherapy in patients with esophageal squamous cell carcinoma with local lymph node metastasis on their blood tumor markers and immunological indicators.Methods 130 esophageal squamous cell carcinoma patients(116 included in the study) who were treated in Anyang Tumor Hospital for local lymph node metastasis were selected and divided into observation group and control group according to the random number table method, 58 cases in each group.The control group received gamma knife radiotherapy.It combined the observation group with Paclitaxel/Cisplatin(TP) chemotherapy based on the control group.Clinical efficacy of 1 month after treatment and the differences in blood tumor markers, cellular immunological indicators, and humoral immunological indicators before and after treatment were compared between the two groups.Results(1) There was no significant dyfference in clinical efficacy between the two groups of patients(χ~2=2.157,P=0.142).(2) The two groups of patients before and after treatment were cytokeratin 19 fragment antigen 21-1(CYFRA21-1),squamous cell carcinoma antigen(SCC),carcinoembryonic antigen, CEA) The level difference was statistically different(P<0.05).(3) The observation group CD3,CD8,CD56/CD3,CD16/CD3 were significantly higher than those in the control group, CD4 was significantly lower than that in the control group(P<0.05).(4) The levels of IgG,IgM,IgA,C3,and C4 were poor before and after treatment in the two groups the values were statistically different(P<0.05).Conclusion Gamma knife combined with chemotherapy in the treatment of patients with esophageal squamous cell carcinoma with local lymph node metastasis can effectively reduce the levels of CYFRA21-1,SCC,and CEA,improve the body’s humoral and cellular immunity, and improve the patient’s own immunity.

【基金】 河南省医学科技攻关计划项目(2018021016)
  • 【文献出处】 牡丹江医学院学报 ,Journal of Mudanjiang Medical University , 编辑部邮箱 ,2021年04期
  • 【分类号】R735.1
  • 【被引频次】1
  • 【下载频次】49
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