【摘要】 目的:探讨¹⁸F-FDG PET/CT在脂膜炎性T细胞淋巴瘤（SPTCL）诊疗中的应用价值。方法:选择2007年8月—2021年6月经病理确诊为SPTCL且治疗前行¹⁸F-FDG PET/CT检查的13例患者,回顾性分析其¹⁸F-FDG PET/CT影像学表现（病灶的分布、大小、最大标准摄取值（SUVmax）等）,分析¹⁸F-FDG PET/CT影像学表现与IPI评分等临床信息的关系,并初步探讨¹⁸F-FDG PET/CT显像对SPTCL疗效评估的价值。结果:¹⁸F-FDG PET/CT影像学表现:皮肤受累13例,病变多位于躯干和四肢,SUVmax为8.16±1.66（躯干:6.53±1.32,四肢:3.61±0.32）;淋巴结受累6例,最大径为（1.30±0.12） cm,SUVmax为4.74±1.03,最大径与SUVmax呈正相关（P=0.031）;骨髓受累7例,SUVmax为4.77±2.92;脾脏受累2例,SUVmax为2.85±0.92;其他脏器受累9例,SUVmax为4.43±0.79。IPI高危组患者9例,病灶SUVmax更高（P=0.035）,皮肤受累部位更多（P=0.047）。有效随访6例,完全缓解2例,部分缓解2例,复发2例,其中3例经PET/CT检查后改变治疗方案获得缓解。结论:在¹⁸F-FDG PET/CT显像上SPTCL病灶均表现为高代谢,因此¹⁸F-FDG PET/CT显像可用于SPTCL的诊断、分期、疗效评价等方面,具有进一步临床推广的应用潜能。更多还原

【Abstract】 Objective: To investigate the application of¹⁸F-FDG PET/CT in subcutaneous panniculitis-like T cell lymphoma（SPTCL）. Methods: The study retrospectively analyzed the clinical and¹⁸F-FDG PET/CT data before treatment of 13 patients with SPTCL diagnosed pathologically from August 2007 to June 2018. The size, distribution, the maximum standardized uptake values（SUVmax） of lymphoma lesions in¹⁸F-FDG PET/CT were collected and analyzed. The relationships between the characteristic of¹⁸F-FDG PET/CT and clinical information（such as IPI scores） in SPTCL patients were analyzed. The value of¹⁸F-FDG PET/CT in the treatment determination and efficacy evaluation was explored. Results: All the 13 patients displayed the skin involvement with SUVmax 8.16 ±1.66, most commonly on the extremities with SUVmax 6.53 ±1.32 and trunk with SUVmax 3.61±0.32. Six cases of SPTCL showed lymph nodes invasion, whose maximum diameter was（1.30±0.12） cm and SUVmax was 4.74±1.03, there was a positive between the maximum and SUVmax of lymph node involvements（P=0.031）. Seven cases of SPTCL showed bone marrow involvement with SUVmax 4.77 ±2.92. Two cases of SPTCL showed splenomegaly with SUVmax 2.85 ±0.92. The SUVmax of other extranodal involvements was 4.43 ±0.79. There were 9 patients in IPI high-risk group. The IPI high-risk group had higher SUVmax of the lesions（P=0.035） and wider distribution of the skin lesions（P=0.047）than in the low-risk group. In 6 cases of SPTCL with effective follow-up, 2 patients showed complete response（CR）, 2 patients showed partial response（PR）, 2 patients showed recurrence. Among them, 3 patients were relieved because of the treatment change after PET/CT checking. Conclusion:¹⁸F-FDG PET/CT is of great value in the diagnosis, staging, efficacy evaluation, and monitoring prognosis of SPTCL, and has the potential for further clinical application.更多还原