【摘要】 目的 :探讨正常颈动脉内-中膜厚度(IMT)人群中,极速脉搏波技术(UFPWV)测量的动脉弹性与动脉粥样硬化(AS)发生之间的关系,为正常IMT人群预防AS提供影像学依据。方法:选取进行流行病调查中IMT正常的人群(n=157)为研究对象,记录年龄、性别及吸烟史,测量身高、体质量、收缩压(SBP)及舒张压(DBP),并计算体质量指数(BMI)。超声测量IMT,应用UFPWV测量收缩期起始时脉搏波传导速度(PWVBS)以及收缩期结束时脉搏波传导速度(PWVES),检验获得空腹血糖(FPG)、甘油三酯、总胆固醇、高密度脂蛋白及低密度脂蛋白。3年后对同一人群再次行颈动脉超声检查,将IMT≥1.5 mm者纳入AS组(n=32),IMT<1.5 mm者纳入非AS组(n=125)。回顾性比较两组间相关因素差异。Logistic回归分析影响动脉粥样硬化发生的危险因素。结果:(1)AS组年龄、男性占比、IMT、SBP、DBP、PWVES及吸烟率高于非AS组,FPG低于非AS组(P<0.05)。(2)Logistic回归分析结果显示PWVES及吸烟是影响AS的危险因素。结论:正常IMT人群中,PWVES可以早期检测出颈动脉管壁弹性减低。颈动脉弹性减低可导致正常IMT人群患AS风险增加。颈动脉PWVES作为一种影像学指标,可以用于临床评估动脉管壁弹性,指导正常IMT人群健康管理以及预防AS发生。更多还原

【Abstract】 Objective: To investigate the correlation between arterial elasticity measured by ultrafast pulse wave velocity(UFPWV) and the occurrence of atherosclerosis(AS) in normal carotid intima-media thickness(IMT) population, and to provide imaging basis for the prevention of AS in normal IMT population. Methods: Normal IMT population(n=157) was investigated by epidemiology. Age, gender and smoking history were recorded; Height, weight, systolic blood pressure(SBP) and diastolic blood pressure(DBP) were measured, and body mass index(BMI) was calculated. IMT was measured by ultrasound, and pulse wave velocity at the beginning of the systole(PWVBS) and pulse wave velocity at the end of the systole(PWVES) were measured by UFPWV. Harvest fasting plasma glucose(FPG), triglycerides, total cholesterol, high-density lipoprotein and low-density lipoprotein. Three years later, carotid ultrasound was performed again in the same population. Population with IMT ≥1.5 mm were included in AS group(n=32), while those with IMT<1.5 mm were included in non-AS group(n=125). The differences of related factors between the two groups were retrospectively compared. Logistic regression was used to analyze the risk factors of atherosclerosis. Results:(1)Compared to non-AS group, age, the percentage of males, IMT, SBP, DBP, PWVES and smoking rate were higher, while FPG was lower in AS group(P<0.05).(2)Logistic regression analysis showed that PWVES and smoking were the risk factors affecting AS. Conclusion: In normal IMT population, PWVES can detect carotid wall elasticity decrease at early stage. Reduction carotid artery elasticity is associated with an increased risk of AS in normal IMT population. As an imaging index, PWVES of carotid artery can be used for clinical evaluation of arterial wall elasticity, guidance of health management in normal IMT population and prevention of AS.更多还原