【摘要】 目的 :探讨动态床旁肺超声评分(Lung ultrasound score,LU score)预测早产儿支气管肺发育不良(Bronchopulmonary dysplasia,BPD)程度的临床价值。方法:选取临床诊断为BPD的早产儿60例在出生后第1～2天进行床旁肺超声检查并计算LU score,以后每周检查评分1次,直至出生后28 d,共检查评分5次,按照BPD严重程度分轻、中、重3组,分析LU score与不同程度BPD的关系。结果:出生后第1～2天及第1、2、3、4周,5个时间点的LU score在轻、中、重度BPD之间差异有统计学意义(P<0.05),LU score随着BPD轻、中、重程度5个时间点变化而逐级增加。ROC曲线分析显示,出生后第1～2天及第1、2、3、4周LU score预测中重度BPD的ROC曲线下面积分别为0.686、0.769、0.762、0.808、0.854;以LU score 13.5分(第1～2天)、8.5分(第1周)、9.5分(第2周)、10.5分(第3周)、9.5分(第4周)预测中重度BPD的敏感度分别为46.50%、79.10%、81.40%、65.1%、62.80%,特异度分别为100%、52.90%、64.70%、82.40%、88.20%。结论:动态床旁LU score在预测早产儿BPD严重程度方面有一定的临床参考价值。更多还原

【Abstract】 Objective: To evaluate the clinical value of dynamic bedside lung ultrasound(LU) score in predicting the degree of bronchopulmonary dysplasia(BPD) in premature infants. Methods: Sixty premature infants with BPD were examined by bedside LU at 1～2 days after birth, and then weekly until 28 days after birth. And the LU score of each examination were calculated. According to the severity of BPD, the premature infants were divided into mild, moderate and severe groups. And the relative between LU scores and the severity of BPD was analyzed. Results: The LU score of 5 time points from 1～2 days after birth to 28 days achieved a significant difference among mild, moderate and severe BPD, and the LU score increased with the severity of BPD. Area under ROC curve of moderate and severe BPD was predicted by LU score at 1～2 days after birth, 1, 2, 3 and 4 weeks after birth were 0.686, 0.769, 0.762, 0.808 and 0.854. LU score 13.5 points, 8.5 points, 9.5 points, 10.5 points, 9.5 points to predict the sensitivity of moderately severe BPD were respectively 46.50%, 79.10%, 81.40%,65.1%, 62.80%, and specificity were 100%, 52.90%, 64.70%, 82.40%, 88.20%. Conclusion: Dynamic bedside LU score has a certain clinical value for predicting the severity of BPD.更多还原