【摘要】 目的研究糖尿病与髋部骨折的相关性,对所有已获得的数据进行系统综述和Meta分析,评价糖尿病是否增加髋部骨折的发生风险。方法依据Meta分析要求,对维普、万方、Springer、Science Direct、CBM、PubMed、Embase、Cochrane、Library、和Web of science数据库CBM、CNKI、Embase、中国科技论文统计与分析网、专利数据库等中英文数据库等进行检索,严格评价纳入糖尿病患者与一般人群发生髋部骨折的对照实验研究文献,并收录有效的相关数据资料,检索年限从2018年1月1日至今。分别采用NOS文献质量评价标准对符合纳入排除标准的文献进行质量评价;采用Q检验和I2统计量检验对纳入文献进行异质性研究及leave one out的敏感性分析;采用Egger’s检验和Begg’s检验评价纳入文献的发表偏倚。结果最终纳入29篇文献,受试者共计8 453 193例,6 430 654例一般人群中发生髋部骨折110 752例,2 022 539例糖尿病患者中发生髋部骨折33 954例。经Meta分析得出糖尿病患者的髋部骨折风险高于非糖尿病患者(OR=1.507,95%CI:1.238,1.834,Z=4.09,P<0.1)。结论糖尿病可增加患者髋部骨折发生风险。更多还原

【Abstract】 Objective To investigate the correlation between diabetes and hip fracture, and to systematically review and analyze all available data to evaluate whether diabetes mellitus increases the risk of hip fracture. Methods According to the requirements of Meta analysis, we have a wide range of products and services, including Vip, Wanfang, Springer, Science Direct, CBM, PubMed, Embase, Cochrane, Library,and Web of Chinese and English databases such as CBM, CNKI, EMBASE, China Statistical and Analytical Network of Scientific and Technological Papers, Patent Database, etc. The literatures of controlled experimental studies on hip fracture in diabetic patients and the general population were strictly evaluated and valid relevant data were included. The retrieval period was from January 1,2018 to the present. NOS literature quality assessment criteria were used to evaluate the quality of literatures that met the inclusion and exclusion criteria. Q test and I2 statistic test were used to study the heterogeneity of the included literatures and sensitivity analysis of leave one out. Egger’s test and Begg’s test were used to evaluate the publication bias of the included literatures. Results A total of 29 studies were included, including 8,453 193,subjects. There were6,430,654 subjects from the general population, 110,752 patients with hip fracture, 2,022,539 patients with diabetes, and 33,954 patients with hip fracture. Diabetic patients had a higher risk of hip fracture than non-diabetic patients(OR=1.507, 95% CI: 1.238, 1.834, Z=4.09, P<0.1). Conclusion Meta-analysis shows that diabetes may increase the risk of hip fracture.更多还原