【摘要】 肺癌是世界范围内发病率和病死率均位居前列的实体肿瘤，以非小细胞肺癌（non-small cell lung cancer, NSCLC）为主，且老年患者占比较高。老年NSCLC患者的治疗一直是临床上棘手的问题。近年来，随着治疗手段的进步以及各种靶向、免疫治疗药物的开发，很多新药和新的疗法都为老年NSCLC患者提供了有效的临床解决方案。对于早期具备手术条件的老年NSCLC患者，相比于传统开胸手术，电视胸腔镜外科手术是更好的选择，既可以实现根治手术，也可以有效减少手术并发症，改善预后。对于不具备手术条件的患者，靶向及免疫新辅助治疗是除了辅助化疗之外手术前后辅助治疗的新选择，使晚期NSCLC老年患者也有靶向、免疫、化疗、放疗及联合治疗等多种治疗方案，使老年NSCLC患者的预后得到有效改善，实现个体化精准治疗。本文拟对老年NSCLC患者的治疗研究进展做一综述，以期为临床治疗提供参考意见。更多还原

【Abstract】 Lung cancer is a solid tumor with high morbidity and mortality. Non-small cell lung cancer(NSCLC) is the most common type of lung cancer, and elderly patients account for a high proportion of NSCLC patients. Treatment of NSCLC in elderly patients has always been a challenge in clinic. However, in recent years, the treatment of NSCLC has made rapid progress. Many new drugs and new therapies have provided effective clinical solutions for elderly patients. For elderly patients with early NSCLC, video-assisted thoracic surgery is a better choice than traditional open-chest surgery, which can achieve radical surgery and effectively reduce surgical complications and improve prognosis. For patients who do not have surgical indications, targeted and immunotherapy are new choices of preoperative/postoperative adjuvant therapy in addition to adjuvant chemotherapy, and even patients with advanced NSCLC have a variety of regimens such as targeted therapy, immunotherapy, chemotherapy, radiotherapy and combination therapy, so that the prognosis of elderly NSCLC patients can be effectively improved and individualized precision treatment can be realized. This article reviews the progress on the treatment of NSCLC in elderly patients, so as to provide reference for clinical treatment.更多还原