【摘要】 目的评价Centurion主控液流系统开展白内障超声乳化术的临床获益。方法前瞻性随机临床试验。选择年龄相关性白内障Ⅲ到Ⅴ级核患者81例(81只眼),年龄41～82岁,其中男性35例(35只眼),女性46例(46只眼),随机分为2组,A组(41只眼)采用Centurion白内障智能超声乳化仪的Active Fluidics系统实施白内障超声乳化联合人工晶状体植入手术。B组(40只眼)采用Centurion超声吸除乳化仪的Gravity Fluidics系统实施手术。术后1 d、1周、1个月、3个月时,检查并分析术眼的裸眼视力,矫正视力,角膜内皮细胞数量和前房闪辉情况。结果两组患者术中均无明显浪涌与其他并发症出现,术后裸眼视力、矫正视力、术中负压、流量、有效超声能量、超声时间、两组均无统计学差异;术后1 d和1周时主控液流组与传统灌注组的前房闪辉值分别为:(10.92±0.18) vs.(12.27±0.23)、(7.53±0.14) vs.(7.99±0.25),存在显著性差异(P <0.05);术后3个月主控液流组角膜内皮细胞丢失率(8.59%±0.73%)低于传统重力灌注组(10.45%±1.88%),差异具有统计学意义(P <0.05),前房闪辉和角膜内皮细胞丢失率差异在Ⅳ/Ⅴ级核患者中更加明显。结论主控液流系统提供了白内障手术中更低的目标眼压,有利于减少白内障术后前房闪辉,并降低角膜内皮细胞的丢失率,相较于传统的重力灌注安全性更高。更多还原

【Abstract】 Objective To evaluate the clinical benefits of Centurion active fluidics system on corneal endothelial cells during cataract surgery. Methods A prospective randomized clinical trial was conducted in 81 patients( 81 eyes)with grade Ⅲ to Ⅴ age-related cataract,including 35 males( 35 eyes) and 46 females( 46 eyes),aged 41-82 years. They were randomly divided into 2 groups: Group A( 41 eyes) underwent phacoemulsification and intraocular lens( IOL) implantation with the active fluidics system of Alcon Company’s Centurion vision system and Group B( 40 eyes) was operated with the gravity fluid flow system of Centurion vision system. The visual acuity,corrected visual acuity,number of corneal endothelial cells and anterior chamber flare were observed at 1 d,7 d,1 m,and 3 m after the surgery. Results No obvious anterior chamber collapse was observed in either group during the operation,and there was no statistical difference in the postoperative uncorrected and corrected visual acuity,intraoperative negative pressure,flow rate,effective ultrasound energy,and ultrasound time between the two groups. The anterior chamber flare values of the active fluidics group and the traditional perfusion group at 1 day and 1 week after the surgery were( 10. 92 ± 0. 18) vs( 12. 27 ± 0. 23) and( 7. 53 ± 0. 14)vs( 7. 99 ± 0. 25) respectively,with significant differences( P < 0. 05). The loss rate of corneal endothelial cells in the active perfusion group( 8. 95%) was significantly lower than that in the traditional gravity perfusion group at 3 m after the surgery( 10. 45%,P < 0. 05). Conclusions The active fluidics system provides a lower target intraocular pressure during cataract surgery,which is beneficial to the anterior chamber flare and corneal endothelial cell loss rate after cataract surgery,making it safer than the traditional gravity perfusion.更多还原