【摘要】 目的:评价已发布的肝脏弹性成像技术无创诊断肝纤维化的实践指南,并从循证方法学角度进行解读。方法:由2名研究者检索中英文数据库,截止日期为2020年9月1日。由3名研究者采用AGREEⅡ工具对纳入的指南进行质量评价。结果:共纳入9篇指南。3名研究者的组内相关系数为0.84±0.43,提示一致性很好。纳入指南的AGREEⅡ的6个领域得分的中位数分别为78%、30%、33%、81%、42%和47%。结论:现有指南质量参差不齐,指南的参与人员、制订严谨性、应用性和独立性存在不足,须依据更多高质量的临床研究证据,采用循证指南制定法修订。更多还原

【Abstract】 Objective: To evaluate the published practice guidelines on non-invasive diagnosis of hepatic fibrosis using liver elastography, and interpret the assessment from the perspective of evidence-based methodology.Methods: The related data were collected by two researchers based on the Chinese and English databases until September 1, 2020. The methodological quality of included guidelines was evaluated by 3 reviewers using the AGREE Ⅱ.Results: A total of 9 guidelines were included. The intraclass correlation coefficient of the three researchers was 0.84±0.43, indicating that the overall consistency was good. The median scores of the six domains in AGREE Ⅱ were 78%, 30%, 33%, 81%, 42% and 47%, respectively.Conclusions: The quality of the existing guidelines is uneven, and there are deficiencies in the personnel involved, formulation rigorousness, applicability, and independence of the guidelines. The evidence-based method should be adopted for revisions based on more high-quality clinical research evidences.更多还原