【摘要】 目的探究曲美他嗪联合盐酸法舒地尔对冠心病患者血脂水平、氧化应激反应的影响。方法选取2017年1月至2018年12月于北华大学附属医院接受治疗的稳定型心绞痛冠心病患者200例,按照随机数字表法分为单药治疗组与联合治疗组各100例,单药治疗组使用曲美他嗪进行治疗,20 mg/次,3次/d,联合治疗组使用曲美他嗪联合盐酸法舒地尔进行治疗,30 mg盐酸法舒地尔注射液加入100 mL 9%氯化钠溶液中静脉滴注,3次/d,2组均连续治疗2周。对2组患者心功能进行检查,检测血清肌钙蛋白I(cTnI)、超敏肌钙蛋白I(hs-TNI)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、总胆固醇(TC)、甘油三酯(TG)、丙二醛(MDA)、超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-Px)水平,以及比较2组患者治疗总有效率及不良反应发生情况。结果治疗后联合治疗组患者心输出量(CO)、左心室射血分数(LVEF)均高于单药治疗组(P<0.05);治疗后联合治疗组患者血清cTnI、hs-TNI水平与单药治疗组比较,差异均无统计学意义(P>0.05);治疗后联合治疗组患者血清HDL-C水平高于单药治疗组,LDL-C、TG、TC水平均低于单药治疗组(P<0.05);治疗后联合治疗组MDA水平低于单药治疗组(P<0.05),SOD、GSH-Px水平均高于单药治疗组(P<0.05);联合治疗组患者治疗总有效率高于单药治疗组(93.00%vs.83.00%,P<0.05);联合治疗组患者不良反应发生率略高于单药治疗组,但2组比较差异无统计学意义(P>0.05)。结论曲美他嗪联合盐酸法舒地尔治疗能够改善冠心病患者心功能、血脂指标水平,提升患者抗氧化能力,且具有一定安全性。更多还原

【Abstract】 Objective To investigate the effect of Trimetazidine combined with Fasudil Hydrochloride on blood lipid level and oxidative stress response in patients with coronary heart disease.Methods A total of 200 patients with stable angina pectoris and coronary heart disease treated in the Affiliated Hospital of Beihua University were selected from January 2017 to December 2018.According to the random number table method,100 patients in the single-drug treatment group and 100 patients in the combined treatment group were treated with Trimetazidine,20 mg/time,three times/d.The combined treatment group was treated with Trimetazidine combined with Fasudil Hydrochloride,30 mg of Fasudil Hydrochloride injection was intravenously dripped with 100 mL of 9% Sodium Chloride Solution and 30 mg of Fasudil Hydrochloride injection three times a day for 2 weeks in both groups.The cardiac function of two groups of patients was examined,and the serum levels of troponin I(cTnI),hypersensitive troponin I(hs-TNI),high density lipoprotein cholesterol(HDL-C),low density lipoprotein cholesterol(LDL-C),total cholesterol(TC),triglyceride(TG),malondialdehyde(MDA),superoxide dismutase(SOD),glutathione peroxidase(GSH-Px)were detected,and The total effective rate and adverse reactions of the two groups of patients were compared and compared.Results After treatment,cardiac output(CO)and left ventricular ejection fraction(LVEF)were higher in the combination group than in the single-drug treatment group(P < 0.05).After treatment,the serum levels of HDL-C in the combined treatment group were higher than single-drug treatment group,LDL-C,TG,TC and MDA were lower than those in the single-drug treatment group(P < 0.05).After treatment,the serum MDA level in the combined treatment group was lower than that in the single-drug treatment group,while the MDA level in the combined treatment group was lower than that in the single-drug treatment group(P < 0.05),and the SOD and GSH-Px levels were higher than those in the single-drug treatment group(P < 0.05).The total effective rate in the combined treatment group was higher than that in the single-drug treatment group(93.00% vs.83.00%,P < 0.05).The incidence of adverse reactions in the combined treatment group was slightly higher than that in the single-drug treatment group,but there was no significant difference between the two groups(P > 0.05).Conclusion The use of Trimetazidine combined with Fasudil Hydrochloride in the treatment of patients with coronary heart disease can improve the cardiac function,and blood lipid index level,it can also improve the antioxidant capacity of patients,with a certain safety.更多还原