【摘要】 目的探讨CIN发生的影响因素。方法选择87例CIN患者作为观察组,同期体检病理结果正常者85例作为对照组。检测两组阴道微生态、HPV、TRAIL及IL-32等并进行分析。结果两组阴道微生态各指标相比均有统计学意义(χ~2=5.82～53.45,P<0.05);观察组HPV感染率、IL-32浓度明显高于对照组,TRAIL浓度明显低于对照组(P<0.01)。结论 CIN的发生与阴道微生态异常、HPV感染、低水平TRAIL表达及高水平IL-32表达有一定关系。更多还原

【Abstract】 Objective To explore the influencing factors of CIN. Methods Eighty seven patients with CIN were selected as the observation group, and 85 patients with normal pathological results of physical examination during the same period were selected as the control group. The vaginal microecology, HPV, TRAIL and IL-32 in two groups were detected and analyzed. Results The two groups of vaginal microecological indicators were statistically significant(χ~2=5.82-53.45,P<0.05).The HPV infection rate and IL-32 concentration of the observation group were significantly higher than those of the control group, and the TRAIL concentration was significantly higher than that of the low control group(P<0.01). Conclusion The occurrence of CIN is related to vaginal microecological abnormalities, HPV infection, low-level TRAIL expression, and high-level IL-32 expression.更多还原