【摘要】 [目的]探讨炎症性肠病(IBD)合并高血糖症的临床特点及危险因素。[方法]以合并高血糖症的IBD患者73例为观察组,按照1∶1比例选取年龄、性别与观察组一致的无高血糖症的IBD患者73例为对照组,比较2组患者临床特点的差异,并分析IBD患者发生高血糖的危险因素。[结果]与对照组相比,观察组的凝血功能指标:凝血酶原时间活动度平均值较低,国际标准化比值、纤维蛋白原及D-二聚体的平均值较高,血红蛋白、白蛋白平均值较低;炎症指标:C反应蛋白、血沉、白细胞计数、血小板、中性粒细胞与淋巴细胞比值较高。2组的凝血酶原时间活动度、国际标准化比值、纤维蛋白原、D-二聚体、C反应蛋白、血沉、白细胞计数、中性粒细胞与淋巴细胞比值、白蛋白平均值比较差异有统计学意义(P<0.05),血红蛋白、血小板比较差异无统计学意义(P>0.05)。Logistic回归分析显示合并严重并发症(OR=0.191)、合并肠外表现(OR=0.324)、近期使用激素(OR=0.266)、近期使用抗生素(OR=0.001)与IBD患者的高血糖症明显相关(P<0.05)。[结论]IBD合并高血糖症会使患者的整体炎症状态加重,加重疾病的活动程度,诱发营养不良及严重并发症。更多还原

【Abstract】 [Objective]To investigate the clinical characteristics and related factors of inflammatory bowel disease(IBD)complicated with hyperglycemia.[Methods]Seventy-three IBD patients(Forty-three UC patients and Thirty CD patients)with hyperglycemia were selected as the observation group, seventy-three cases without hyperglycemia who had the same basic information with the observation group patients were selected as the control group.Compared the differences in general condition, laboratory examination, disease activity, treatment plan, complications and extraintestinal manifestations between the two groups, and looked for the related factors of hyperglycemia in IBD patients.[Results]There were significant differences between the observation group and the control group in terms of blood coagulation function, inflammation indicators, nutritional status, complications, parenteral manifestations and treatment,(P<0.05).Logistic regression analysis showed that the severe complications(OR=0.191),combined parenteral manifestations(OR=0.324),recent use of systemic hormones(OR=0.266)and recent use of antibiotics(OR=0.001)were significantly correlated with hyperglycemia in IBD patients(P<0.05).[Conclusion]The combination of IBD and hyperglycemia may aggravate the overall inflammatory state of patients, aggravate the degree of disease activity, and induce malnutrition and serious complications.The use of glucocorticoids and enteral nutrition may be the inducement of the new hyperglycemia, while biological agents may be the protective factor.更多还原