【摘要】 目的探究阿尔茨海默病（AD）患者脑部[¹⁸F]-APN-1607PET显像的tau蛋白沉积与MRI的脑皮质萎缩的相关性。方法纳入25例AD患者为AD组和10例健康受试者为对照组。受试者均行脑部[¹⁸F]-APN-1607 PET显像和头颅MRI T1显像。计算受试者各脑区tau蛋白负荷及大脑皮质萎缩程度,分析tau蛋白标准摄取值比值（SUVR）与相对灰质萎缩比值的相关性。结果 AD组在大脑皮质（额、顶、颞、枕、前后扣带回）存在弥漫性tau蛋白沉积,tau蛋白SUVR均显著高于对照组,且上述各脑区的相对灰质萎缩比值均低于对照组。AD组的tau蛋白SUVR与相对灰质萎缩比值在除前扣带回以外的所有脑区存在显著相关性（P<0.05,R=0.402～0.572）。结论 [¹⁸F]-APN-1607 PET显像可反映AD患者tau蛋白异常沉积与大脑皮质萎缩之间的密切相关性。更多还原

【Abstract】 Aim To investigate the correlation between cerebral tau protein deposition based on [¹⁸F]-APN-1607 PET imaging and MRI-based cortical atrophy in Alzheimer’s disease（AD）. Methods Twenty-five patients with AD and 10 healthy controls（HS） were included. Tau protein burden and gray matter atrophy severity in each brain region of subjects were calculated, and the correlation between Standardized Uptake Value Ratio（SUVR） and regional atrophic grey matter ratio was analyzed. Results Diffuse tau protein deposition were observed in cerebral cortices（frontal, parietal, temporal, occipital, anterior and posterior cingulate gyrus） in AD group, with significantly higher SUVR than those in HS group, and the regional grey matter ratio were lower than those in HS group. There was a significant correlation between tau protein SUVR and regional grey matter atrophic ratio in all brain regions except the anterior cingulate gyrus（P<0.05, R=0.402-0.572）. Conclusion [¹⁸F]-APN-1607 PET imaging can reflect the significant correlation between abnormal deposition of tau protein and cerebral cortex atrophy in patients with AD.更多还原