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钙稳态、维生素D与糖尿病认知损害关系的研究进展

Research Progress on the Relationship between Calcium Homeostasis, Vitamin D and Cognitive Dysfunction in Diabetes

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【作者】杨东梅；董齐；伊然；苑春兰；董舒馨；张冰冰；于丹；代瑞雪；关爽；程雪娇；张歌；张译丹；郑晓蓉；曹海玲；陈本伟；赵静；唐晶；

【Author】 YANG Dong-mei;DONG Qi;YI Ran;YUAN Chun-lan;DONG Shu-xin;ZHANG Bing-bing;YU Dan;DAI Rui-xue;GUAN Shuang;CHENG Xue-jiao;ZHANG Ge;ZHANG Yi-dan;ZHENG Xiao-rong;CAO Hai-ling;CHEN Ben-wei;ZHAO Jing;TANG Jing;Department of Neurology, the First Afilited Hospital of Harbin Medical University;Department of Endocrine, the First Affilited Hospital of Harbin Medical University;Department of Emergency, the First Hospital of Jilin University;Department of Neurology, Jining First People’s Hospital;Heilongjiang Provincial Hospital;Department of Neurology, 962 Hospital, Joint Logistics Support Force of Chinese People’s Liberation Army;Hemodialysis Center of Jiaxing Second Hospital;West China Hospital of SichuanUniversity;Ankang Central Hospital of Shanxi;Harbin Second Hospital;Department of Neurology, the Afiliated Hospital of Jilin Medical College;

【通讯作者】董齐;伊然;

【机构】哈尔滨医科大学附属第一医院神经内科；哈尔滨医科大学附属第一医院内分泌科；吉林大学第一医院二部急诊科；济宁市第一人民医院神经内科；黑龙江省医院老年神经内科；中国人民解放军联勤保障部队第九六二医院神经内科；嘉兴市第二医院血液透析中心；四川大学华西医院；陕西省安康市中心医院神经内科；哈尔滨市第二医院神经内科；吉林医药学院附属医院神经内科；

【摘要】随着糖尿病的发病率和老龄化人群的不断增加,与糖尿病相关的认知损害日益引起人们的重视。近年研究发现,钙稳态失衡广泛存在于糖尿病认知损害发生、发展中的多个重要机制中,而维生素D可以在多种细胞类型中通过基因组和非基因组机制调节细胞内Ca²⁺信号并影响细胞膜钙泵表达及钙通道活性调节细胞内钙稳态,对糖尿病认知损害有重要的保护作用。因此,对罹患糖尿病风险增加的人群和糖尿病患者定期监测维生素D水平,且对维生素D缺乏者早期评定认知功能具有重要意义。更多还原

【Abstract】 With the prevalence of diabetes and the increasing number of aging people, cognitive dysfunction related to diabetes has attracted increasing attention. Recent studies have found that the imbalance of calcium homeostasis widely exists in many important mechanisms of the occurrence and development of diabetic cognitive impairment. Vitamin D can regulate intracellular calcium homeostasis through genomic and non genomic mechanisms, and affect the expression of cell membrane calcium pump and the activity of calcium channel in a variety of cell types, which has an important protective effect on diabetic cognitive impairment. Therefore, it is of great significance to regularly monitor vitamin D levels in people with increased risk of DM and patients with DM, and to evaluate cognitive function in patients with vitamin D deficiency at an early stage.更多还原

【关键词】钙稳态；维生素D；糖尿病；认知损害；
【Key words】 calcium homeostasis； vitamin D； diabetes； cognitive dysfunction；

【基金】黑龙江省卫生健康委科研课题(编号：2020-121);哈医大一院科研创新基金(编号：2019M01)

【文献出处】中国临床神经科学 ,Chinese Journal of Clinical Neurosciences , 编辑部邮箱 ,2021年01期

【分类号】R587.2
【被引频次】1
【下载频次】223

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