【摘要】 目的:探讨复发抑郁症患者自传体记忆与临床特征的关系,以及自传体记忆损害是否是抑郁症复发的风险因素。方法:对65例复发抑郁症患者(复发组)以及54例首发抑郁症患者(首发组)采用汉密尔顿抑郁量表(Hamilton depression scale, HAMD-17)及汉密尔顿焦虑量表(Hamilton anxiety scale, HAMA)评定抑郁与焦虑症状,采用自传体记忆测验评定自传体记忆水平。结果:(1)与首发组相比,复发组起病年龄更早、病程更长、抑郁症家族史比例更高、认知障碍更严重、概括性记忆更多(P<0.05或P<0.01);(2)相关分析显示复发组概括性记忆与起病年龄、阳性家族史、认知障碍、迟缓因子呈正相关(r=0.45,0.38,0.39,0.39;P均<0.01);(3)多因素Logistic回归分析显示概括性记忆是与抑郁症复发相关的危险因素。结论:复发抑郁症患者概括性记忆较多,其与起病年龄、阳性家族史、认知障碍与迟缓因子相关,对预测抑郁症复发具有一定的参考价值。更多还原

【Abstract】 Objective:To explore the autobiographical memory of patients with recurrent depression and its relevance with clinical characteristics, and investigate whether autobiographical memory deficit is a risk factor for recurrent depression. Method:65 recurrent depression patients(the recurrent group) and 54 first-episode depression patients(the first-episode group) were assessed depression and anxiety symptoms with 17-item Hamilton Depression Scale(HAMD-17),Hamilton Anxiety Scale(HAMA) and autobiographical memory with autobiographical memory test. Results:(1) The recurrent group had earlier age of onset and longer course of depression, more proportion of family history, higher scores of cognitive dysfunction and overgeneral autobiographical memory(OGM) than the first-episode group(P<0.05 or P<0.01).(2)The correlation analysis showed that OGM score was positively correlated with the age at onset, family history of depression, cognitive disorder and slow factor scores in the recurrent group(r=0.45,0.38,0.39,0.39,respectively; all P<0.01).(3)The multiple stepwise Logistic regression analysis showed that OGM was risk factor for recurrent depression. Conclusion:The patients with recurrent depression have higher OGM,which is correlated with age of onset, positive family history, cognitive disorder and slow factor.The OGM has a certain role for prediction of recurrent depression.更多还原