【摘要】 目的:探讨抑郁症患者急性期疗效对巩固期服药依从性的影响。方法:入组急性期治疗结束的抑郁症患者428例,290例完成6个月随访,分为依从性好组(202例)和依从性差组(88例)。使用16项抑郁症状快速评估量表(QIDS-SR16)、健康问卷躯体化症状群量表(PHQ-15)、广泛性焦虑自评量表(GAD-7)、简明幸福与生活质量满意度问卷(Q-LES-Q-SF)、席汉残疾量表(SDS)等评估急性期治疗结束抑郁症残留症状、生命质量与社会功能对患者巩固期服药依从性的影响。结果:依从性差组QIDS总分、QIDS-5、QIDS-11、QIDS-13、QIDS-14、PHQ-15总分、GAD-7总分、SDS-03得分高于依从性好组,Q-LES-Q-SF总分低于依从性好组,组间差异有统计学意义(P<0.05或P<0.01)。多元Logistic回归分析显示急性期末PHQ-15总分及QIDS-11得分与巩固期服药依从性差有显著关联(P<0.05)。结论:抑郁症急性期治疗后残留症状越多、生活质量越差,患者巩固期服药依从性越差。更多还原

【Abstract】 Objective:To investigate the effect of outcome after acute treatment on medication adhenerce in consolidation stage in patients with depression. Method:428 patients with acute depression were recruited.290 patients completed 6-month follow-up study, who were divided into the good adhenerce group(n=202) and the poor adhenerce group(n=88).Using Brief 16-item Quick Inventory of Depressive Symptomatology Self-Report(QIDS-SR16),Patient Health Questionnaire-15(PHQ-15),Self-rating Generalized Anxiety Disorder Scale-7(GAD-7),Quality of Life Enjoyment and Satisfaction Questionnaire-Short Form(Q-LES-Q-SF),Sheehan Disability Scale(SDS) to evaluate the effects of residual symptoms, quality of life and social function at the end of acute phase treatment on patients’ medication adherence in consolidation stage. Results:Total QIDS score, factor scores of QIDS-5, QIDS-11,QIDS-13,QIDS-14,the total scores of PHQ-15 and GAD-7 and SDS-03 score in the poor adherence group were higher than those in the good adherence group and total Q-LES-Q-SF score was lower than that in the good adherence group.The differences between the two groups were statistically significant(P<0.05 or P<0.01).Multiple Logistic regression analysis showed that total score of PHQ-15 and QIDS-11 score at the end of acute phase treatment were significantly associated with poor medication adherence in consolidation stage(P<0.05). Conclusion:The more residual core symptoms and the worse quality of life after treatment of depression in the acute stage, the worse the medication adherence in the consolidation stage.更多还原