【摘要】 目的:探讨伴或不伴代谢综合征(MS)的精神分裂症患者抑郁症状的差异及其影响因素。方法:本研究采用横断面研究设计纳入奥氮平单药治疗两年以上的精神分裂症患者239例,分为MS组(n=110)或非MS组(n=129)。采用阳性和阴性症状量表(PANSS)评定精神分裂症患者精神症状,卡尔加里抑郁症状评定量表(CDSS)用于评估精神分裂症患者抑郁水平。结果:两组奥氮平使用时间和剂量差异具有统计学意义(P均<0.05)。MS组体质量指数(BMI)、腰围、空腹血糖(GLU)、三酰甘油(TG)、收缩压(SBP)及舒张压(DBP)水平显著高于非MS组(P均<0.01),而高密度脂蛋白胆固醇(HDL)水平显著低于非MS组(P<0.01)。多因素方差分析显示MS组CDSS评分高于非MS组(P<0.01)。CDSS评分与BMI(t=2.29,P=0.02)、GLU水平(t=2.34,P=0.02)以及TG水平(t=2.13,P=0.03)呈正相关。结论:伴有MS的精神分裂症患者抑郁症状严重,与BMI、GLU以及TG相关。更多还原

【Abstract】 Objective: To investigate the difference of depressive symptoms and its influencing factors in schizophrenic patients with or without metabolic syndrome(MS). Method:A cross-sectional study was conducted in 239 patients with schizophrenia who had been treated with olanzapine monotherapy for more than 2 years.The patients were divided into MS group(n=110) and non-MS group(n=129).The Positive and Negative Symptom Scale(PANSS) was used to evaluate psychotic symptoms.Calgary Depression Scale for Schizophrenia(CDSS) was used to evaluate depressive symptoms. Results:There were significant differences in the duration and dosage of olanzapine treatment between the two groups(all P<0.05).The results showed that the levels of body mass index(BMI),waist circumference,fasting glucose(GLU),triglyceride(TG),triglyceride(SBP) and diastolic blood pressure(DBP) in the MS group were significantly higher than those in the non-MS group(all P<0.01),and the level of high density lipoprotein(HDL) was significantly lower than that in the non-MS group(P<0.01).Multivariate analysis of variance showed that CDSS score in the MS group was higher than that in the non-MS group(P<0.01),which was positively correlated with BMI(t=2.29,P=0.02),GLU(t=2.34,P=0.02) and TG(t=2.13,P=0.03). Conclusion:Schizophrenic patients with MS have more severe depressive symptoms, associated with BMI,GLU and TG levels.更多还原