【摘要】 胆管癌是最为常见的胆道恶性肿瘤,具有较高的死亡率,且其发病率逐年上升。早期症状不典型和复杂的解剖位置,常常导致胆管癌患者难以早期得到确诊,错过最佳治疗时期,预后不良。近年来,miRNA被证明在胆管癌发生发展的病理生理过程中起着关键作用。简述了miRNA在胆管癌的发生、侵袭和转移、耐药、肿瘤微环境中的调节作用,并介绍了外泌体miRNA与胆管癌相关的新进展,以期为胆管癌提供潜在的治疗策略。更多还原

【Abstract】 Cholangiocarcinoma is the most common malignant tumor of the biliary tract,with a relatively high mortality rate and an incidence rate increasing year by year. Due to atypical symptoms in the early stage and complex anatomical location,it is often difficult for patients with cholangiocarcinoma to be diagnosed in the early stage,and therefore,they often miss the optimal treatment period and tend to have poor prognosis. In recent years,studies have shown that miRNAs play a key role in the pathophysiological process of the development and progression of cholangiocarcinoma. This article reviews the regulatory role of miRNAs in the development,invasion,metastasis,drug resistance,and tumor microenvironment of cholangiocarcinoma and introduces the latest advances in exosome miRNA and cholangiocarcinoma,so as to provide potential treatment strategies for cholangiocarcinoma.更多还原