【摘要】 非酒精性脂肪性肝病(NAFLD)是一种常见疾病,病理表现为肝细胞内脂肪滴大量蓄积。NAFLD不仅成因复杂,还可诱发心血管疾病、糖尿病等,然而目前尚无有效的治疗手段和专门的治疗药物。自噬在真核生物中普遍存在,具有维持细胞内稳态的作用。自噬选择性降解细胞中脂质的机制称为脂噬,该机制为缓解因脂质蓄积引起的疾病提供了新思路。从NAFLD发生发展、脂肪滴降解过程、肝脏炎症和纤维化进展相关因子入手,探讨了自噬与NAFLD的相关性。这可能为从自噬入手治疗NAFLD提供理论基础,并为相关药物的研发提供作用靶点。更多还原

【Abstract】 Nonalcoholic fatty liver disease( NAFLD) is a common disease characterized by the accumulation of lipid droplets( LDs) in hepatocytes. Clinical studies have shown that NAFLD not only has complex causes,but also can induce cardiovascular diseases and diabetes;however,there are still no effective therapies and specific drugs for this disease. Autophagy is ubiquitous in eukaryotes and has the function of maintaining cellular homeostasis. The mechanism of selective degradation of lipids in cells by autophagy is called lipophagy,which provides new thoughts for alleviating diseases caused by lipid accumulation. This article analyzes the association between autophagy and NAFLD in terms of the development and progression of NAFLD,the degradation of LDs,and related factors for the progression of liver inflammation and fibrosis,in order to provide a theoretical basis for the treatment of NAFLD from autophagy and provide targets for the development of related drugs.更多还原