【摘要】 牙周炎是导致成年人牙齿缺失的最主要原因,理想的治疗目标是重建缺损的牙周组织,恢复牙齿的功能。近年来研究发现,干细胞诱导组织再生的能力来源于其旁分泌特性,其分泌的各种生物活性因子存在于间充质干细胞条件培养基(MSC-CM)中,发挥免疫调节和抗炎活性,调控细胞的迁移、增殖及分化,促进血管新生及牙周组织的修复。本文探讨了MSC-CM的基本概念及其应用于牙周组织再生方面的研究进展。更多还原

【Abstract】 Periodontitis is the leading cause of tooth loss in adults. Rebuilding the defected periodontal tissue and restoring the tooth function are the ideal goal. In recent years, it has been found that the ability of stem cells to induce tissue regeneration is derived from paracrine characteristic. Various biological factors secreted by them exist in the conditioned medium(MSC-CM), exert immune regulation and anti-inflammatory function, regulate cell migration, proliferation, and differentiation, and promote angiogenesis and periodontal tissue repair. This article reviews the basic concepts of MSC-CM and its application for periodontal tissue regeneration.更多还原