【摘要】 目的探讨浓缩生长因子(concentrated growth factor, CGF)对前臂皮瓣供区术后感觉恢复的影响。方法回顾性分析2019年7月至2020年7月南京医科大学附属口腔医院采用前臂皮瓣修复颌面部缺损的30例患者,其中试验组16例,对照组14例。试验组术中制备CGF,覆盖于暴露的桡神经上,对照组不做处理。术后1、3、6个月复诊随访,采用定量感觉测试测量虎口区感觉,比较两组术后供区感觉的恢复情况。统计学方法采用曼-惠特尼秩和检验及独立样本t检验,P<0.05表示结果有统计学差异。结果试验组机械感觉阈值(3、6个月)以及机械痛觉阈值、压力痛觉阈值(1、3、6个月)均优于对照组,差异有统计学意义(P<0.05),两组术后1、3个月的冷痛觉阈值无统计学差异(P=0.417,P=0.151),两组冷感觉阈值、热感觉阈值、热痛觉阈值(1、3、6个月)及冷痛觉阈值(6个月)均有统计学差异(P<0.05)。结论 CGF可促进前臂供区术后感觉的恢复。更多还原

【Abstract】 Objective To investigate the effect of concentrated growth factor on somatosensory changes at forearm donor site. Methods Thirty patients who underwent reconstruction with radial forearm flap from July 2019 to July 2020 in the Affiliated Hospital of Stomatology, Nanjing Medical University were enrolled in this study, including 16 cases in experimental group and 14 cases in control group. In the experimental group, CGF was prepared during the operation and covered on the exposed radial nerve, while the control group was left untreated. After 1, 3, and 6 months of follow-up, quantitative sensory test was assessed. The difference between the two groups of postoperative sensory recovery was compared. The statistical methods used were Mann-Whitney test and independent sample t test, and P<0.05 indicated statistical difference. Results The difference in mechanical detection threshold between the experimental group and the control group at 3 and 6 months after surgery and the difference between the mechanical pain threshold and pressure pain threshold at 1, 3 and 6 months after surgery were statistically different(P<0.05). There was no statistical difference in cold pain threshold(P=0.417, P=0.151) at 1, 3 months. Cold detection threshold, warm detection threshold and hot pain threshold at 1, 3 and 6 months and cold pain threshold at 6 months between the two groups were statistically different(P<0.05). Conclusion CGF can promote the recovery of postoperative sensation at forearm donor site.更多还原