【摘要】 近年来随着产科高危妊娠的增加及诊断技术的提高,临床对妊娠合并静脉血栓性疾病的关注度逐年增加,尽管已识别出诱发深静脉血栓的各种危险因素,但血栓形成的机制尚不完全清楚。研究表明组蛋白在静脉血栓疾病中有着重要作用,通过TLRs或炎症通路激发炎症,促发血栓形成。旨在对组蛋白通过TLRs激发炎症诱发静脉血栓性疾病作一概述,为以后产科静脉血栓性疾病的预防和治疗提供新的突破点。更多还原

【Abstract】 In recent years,due to the increase of high-risk pregnancies in obstetrics and the improvement of diagnostic techniques, clinical attention to pregnancy complicated with venous thrombotic diseases is increasing from year to year. Although various risk factors that induce deep vein thrombosis have been identified, the mechanism of thrombosis is not yet completely clear. Studies have demonstrated that histones play a key role in venous thrombotic diseases, mediating the production of thrombus through inflammatory pathways or TLRs that activate inflammation.This article aims to provide an overview of histone-induced venous thrombotic diseases through TLRs to stimulate inflammation,and provide a new breakthrough point for the prevention and treatment of obstetric venous thrombotic diseases in the future.更多还原