【摘要】 目的:比较临床药师干预对降低住院患者抗菌药物使用强度和使用率的成效,为促进医院临床合理使用抗菌药物提供参考。方法:选取医院2019年1月—6月间抗菌药物使用各指标(使用强度、使用率及I类切口预防用抗菌药物)发生的数据为干预前组;另选取2019年7月—12月间抗菌药物使用各指标数据为干预后组;比较两组患者抗菌药物使用强度、使用率差异以及I类切口预防用抗菌药物的使用情况。结果:临床药师干预后预防用抗菌药物使用强度由干预前的50.51 DDD/(100人·d)降至40.91 DDD(100人·d)(P<0.05),使用率由50.56%降至45.54%(P<0.05),I类切口预防用抗菌药物比例由26.73%降至24.24%。结论:干预后住院患者抗菌药物使用评价指标得到显著改善,提高了医院合理用药水平,发挥了临床药师的专业作用,同时也增强了临床医师合理使用抗菌药物的意识,确保了患者用药的安全性、有效性、经济性和合理性。更多还原

【Abstract】 Objective:To compare the effectiveness of clinical pharmacists’ before and after intervention on reducing the intensity and utilization rate of antibacterial drugs in in-patients,so as to provide reference for promoting the rational use of antibacterial drugs in hospitals. Methods:The data of all indicators of antimicrobial use(intensity of use,utilization rate and antimicrobial agents for class I incision preventive medication) in the hospital from January to June2019 were selected as the pre-intervention group. In addition,the antimicrobial drug use index data from July to December 2019 were selected as the post-intervention group. The intensity and utilization rate of antimicrobial agents were compared between the two groups,as well as the usage of antimicrobial agents for class I incision prevention. Results:The use intensity of prophylactic antibiotics decreased from 50.51 DDD/(100 persons · d) to 40.91 DDD/(100 persons · d)(P<0.05),the use rate decreased from 50.56% to 45.54%(P<0.05),and the proportion of prophylactic antibiotics for type I incision surgery decreased from 26.73% to 24.24%. Conclusion:After intervention,the evaluation index of antibacterial drug usage in in-patients was significantly improved,enhancing the level of rational drug use in hospitals,playing the professional role of clinical pharmacists,and also enhancing the awareness of clinicians on rational use of antibacterial drugs,finally ensuring the safety,effectiveness,economy and rationality of patients’ drug use.更多还原