【摘要】 丝氨酸蛋白酶抑制剂Serpins是一类参与调控多种生理过程的蛋白酶抑制剂,广泛存在于所有生命体中。本文以黑腹果蝇Drosophila melanogaster、黄粉虫Tenebrio molitor、烟草天蛾Manduca sexta为例,阐述Serpins在昆虫体内诱导抗菌肽产生的Toll信号通路和诱导黑化反应的酚氧化酶酶原(Prophenoloxidase,PPO)激活通路中的调控作用,并以病毒、线虫、细菌和真菌及寄生蜂为例,明确它们产生的Serpins对昆虫宿主免疫系统的调控作用,全面总结和综述了近年来具有Serpin domain结构域的典型Serpins对昆虫免疫的调控作用的研究进展。更多还原

【Abstract】 Serine protease inhibitors(Serpins) are involved in the regulation of various physiological processes common in all living organisms. In this review, we summarize recent published papers on insect serpins involved in the Toll signaling pathway, which produce antimicrobial peptides and regulate the prophenoloxidase(PPO) activation cascade which induces melanogenesis in model insects such as Drosophila melanoganster, Tenebrio molitor and Manduca sexta. In addition, we review research on serpins from entomopathogens, including viruses, nematodes, bacteria, fungi and parasitoids involved in the immuno-regulation of insect hosts.更多还原