【摘要】 目的探讨川芎龙蛭汤联合西医治疗急性脑梗死的疗效及其对机体血清趋化素样因子1（CKLF1）、CXC趋化因子配体16（CXCL16）和不规则趋化因子（FKN）水平的影响。方法选择2019年1月至2020年12月在该院诊断为急性脑梗死患者102例为研究对象,按照随机数字表法将患者分为观察组和对照组,每组51例。对照组予以常规西医治疗,观察组在对照组的基础上使用川芎龙蛭汤治疗。观察两组治疗后的疗效和不良反应发生率,及治疗前后两组血管性痴呆的中医辨证量表（SDSVD）评分、美国国立卫生研究院卒中量表（NIHSS）评分、日常生活活动能力（ADL）评分、平均血流量（Qm）、平均血流流速（Vm）、血管阻力指数（RI）、动脉血氧饱和度（SaO₂）、颈内静脉血氧饱和度（SjvO₂）、脑氧摄取率（CERO₂）、CKLF1、CXCL16和FKN水平的变化。结果观察组的总有效率为90.20%,明显高于对照组的70.59%（χ²=5.038,P<0.05）;治疗后观察组SDSVD评分、NIHSS评分、RI、SjvO₂、CKLF1、CXCL16和FKN水平明显低于对照组（P<0.05）,而ADL评分、Qm、Vm、SaO₂和CERO₂水平明显高于对照组（P<0.05）。结论川芎龙蛭汤联合西医治疗急性脑梗死的疗效显著,能够改善脑部血液供应和氧供应,值得临床推广应用。更多还原

【Abstract】 Objective To observe the efficacy of Chuanxiong Longzhi Decoction combined with Western medicine in the treatment of acute cerebral infarction and its impact on the levels of chemokine-like factor-1（CKLF1）,CXC chemokine ligand 16（CXCL16） and irregular chemokine fractalkine（FKN）.Methods A total of 102 patients with acute cerebral infarction in our hospital from January 2019 to December 2020 were selected and divided into observation group and control group according to random numerical method, and each group had 51 cases.The control group was treated with routinely Western medicine.On the basis of the control group, the observation group was treated with Chuanxiong Longzhi Decoction.The efficacy after the treatment was observed in two groups, and Scale for the Differentiation of Syndromes of Vascular Dementia（SDSVD） score, the National Institutes of Health Stroke Scale（NIHSS） score, activity of daily living（ADL） score, average blood flow（Qm）,average blood flow（Vm）,resistance index（RI）,arterial blood oxygen saturation（SaO₂）,saturation of jugular bulb venous oxygen（SjvO₂）,cerebral oxygen intake（CERO₂）,CKLF1,CXCL16 and FKN levels were also compared between the two groups.Results The total efficiency was 90.20% in the observation group, which was significantly higher than 70.59% in the control group（χ²=5.038,P<0.05）.The levels of SDSVD score, NIHSS score, RI, SjvO₂,CKLF1,CXCL16 and FKN of the observation group were significantly lower than those in the control group（P<0.05）.The ADL scores, Qm, Vm, SaO₂ and CERO₂ levels in the observation group were significantly higher than those in the control group（P<0.05）.Conclusion The efficacy of Chuanxiong Longzhi Decoction combined with Western medicine in the treatment of acute cerebral infarction has obvious efficacy, which can improve the blood supply and oxygen supply of brain.It is worthy of promotion.更多还原