【摘要】 目的探讨载脂蛋白E(ApoE)等位基因多态性对徐州地区高血压患者的影响。方法选取徐州地区临床确诊的高血压患者97例作为高血压组,另选取106例非高血压患者作为对照组。应用PCR-荧光探针法对2组ApoE基因型分别进行检测并统计分析检测结果。结果 ApoE表型和ApoE等位基因频率在2组患者中的表达差异无统计学意义(P>0.05)。在高血压人群中,ε4等位基因携带者的收缩压较其他等位基因携带者高(P<0.05),而ApoE基因多态性对舒张压影响不大(P>0.05)。结论徐州地区ApoE表型和ApoE等位基因频率与高血压疾病无关,ApoE等位基因ε4可能是高血压发生、发展的危险因素。更多还原

【Abstract】 Objective To explore apolipoprotein E(ApoE) allele polymorphism and its relationship in patients with hypertension.Methods Totally 97 patients with hypertension in Xuzhou were selected as hypertension group, and 106 patients without hypertension were selected as control group.The genotypes of ApoE in the two groups were detected by PCR fluorescence probe method, and the results were analyzed statistically.Results There was no significant difference in the expression of ApoE phenotype and allele frequency between the two groups(P>0.05).In people with high blood pressure, the systolic blood pressure of the ε4 allele carriers was higher than that of the other alleles(P<0.05),but the ApoE gene polymorphism had little effect on diastolic blood pressure(P>0.05).Conclusion The phenotype and allele frequency of ApoE are not associated with hypertension in Xuzhou area, ApoE allele ε4 may be a risk factor for the occurrence and development of hypertension.更多还原