【摘要】 目的探讨并研究牙周炎伴慢性阻塞性肺疾病(COPD)急性加重期(AECOPD)患者相关的牙周指标和龈沟液指标,为临床提供诊治依据。方法选取单纯慢性牙周炎(CP)患者、单纯AECOPD患者、中重度CP伴AECOPD患者和全身及牙周健康体检者各30例分别作为CP组、AECOPD组、CP+AECOPD组和对照组。分别对所有研究对象龈沟液炎症因子[白细胞介素(IL)-6、IL-8、C反应蛋白(CRP)和肿瘤坏死因子-α(TNF-α)],以及牙周指标[出血指数(BI)、探诊深度(PD)、临床附着丧失(CAL)、菌斑指数(PLI)]和细菌群落相对丰度进行检测。结果 CP+AECOPD组患者PLI以及CRP、TNF-α、IL-6、IL-8水平明显高于CP组,差异有统计学意义(P<0.05)。在门水平,CP+AECOPD组在厚壁菌门、拟杆菌门、梭杆菌门和变形菌门的相对丰度均明显高于CP组,差异均有统计学意义(P<0.05)。在属水平,CP+AECOPD组在纤毛菌属、棒杆菌属、链球菌属和普氏菌属的相对丰度明显高于CP组,差异均有统计学意义(P<0.05)。结论牙周炎伴AECOPD患者牙周损伤程度高于单纯牙周炎患者,CRP、TNF-α、IL-6、IL-8等炎症因子水平升高以及细菌种类与牙周炎存在密切关系,可为牙周炎患者诊治提供重要依据。更多还原

【Abstract】 Objective To explore and study the related periodontal indexes and gingival crevicular fluid indexes in the patients with periodontitis complicating acute exacerbation of chronic obstructive pulmonary disease(AECOPD) so as to provide a basis for clinical diagnosis and treatment.Methods Each 30 cases of simple chronic periodontitis(CP),simple AECOPD,moderate and severe CP complicating AECOPD and systemic and periodontal healthy subjects undergoing the physical examination were selected as the CP group,AECOPD group,CP + AECOPD group and control group respectively.The gingival crevicular fluid inflammatory factors(IL-6,IL-8,CRP,TNF-α),periodontal indexs(BI,PD,CAL,PLI) and relative abundance of bacterial community in gingival crevicular fluid were detected in all subjects.Results The PLI,CRP,TNF-α,IL-6 and IL-8 levels of the CP + AECOPD group were significantly higher than those of the CP group,and the differences were statistically significant(P<0.05).At the level of phylum,the relative abundance of Chlamydomonas,Bacteroides,Fusobacteria and Proteus in the CP + AECOPD group were significantly higher than that in the CP group,and the differences were statistically significant(P<0.05).At the genus level,the relative abundances of Ciliates,Corynebacterium,Streptococcus and Prevotella in the CP + AECOPD group were significantly higher than those in the CP group,and the differences were statistically significant(P<0.05).Conclusion The degree of periodontal injury in the patients periodontitis complicating AECOPD is higher than that in the patients with simple periodontitis.The increase of inflammatory indexes including CRP,TNF-α,IL-6,IL-8 and bacterial species have the close relation with periodontitis,which can provide an important basis for the diagnosis and treatment of the patients with periodontitis.更多还原