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小P值并不能保证可靠结果:以帕金森病的静息态脑功能成像元分析为例(英文)

Small P values may not yield robust findings: an example using REST-meta-PD

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【作者】 贾熙泽赵娜董昊铭孙家伟Marek BartonRoxana BurciuNicolas CarrièreAntonio Cerasa陈博宇陈俊Stephen CoombesLuc DefebvreChristine DelmaireKathy DujardinFabrizio Esposito范国光Federica Di Nardo冯怡萱Brett W.FlingSaurabh GargMoran GilatMartin GorgesShu-Leong HoFay B.Horak胡晓胡晓飞黄飚黄沛钰贾泽娟Christina JonesJan KassubekLenka KrajcovicovaAjay Kurani李静李晴刘爱萍刘波刘虎刘卫国Renaud Lopes娄毓婷罗巍Tara Madhyastha毛妮妮Grainne McAlonanMartin J.McKeownShirley PangAndrea QuattroneIrena RektorovaAlessia Sarica商慧芳James M.ShinePriyank ShuklaTomas Slavicek宋潇鹏Gioacchino TedeschiAlessandro TessitoreDavid Vaillancourt王健王珏Z.Jane Wang魏鲁庆邬霞徐晓俊闫磊杨靓杨万群姚乃琳张得龙张久权张敏鸣张艳玲周彩红严超赣左西年Mark Hallett吴涛臧玉峰

【Author】 Xi-Ze Jia;Na Zhao;Hao-Ming Dong;Jia-Wei Sun;Marek Barton;Roxana Burciu;Nicolas Carrière;Antonio Cerasa;Bo-Yu Chen;Jun Chen;Stephen Coombes;Luc Defebvre;Christine Delmaire;Kathy Dujardin;Fabrizio Esposito;Guo-Guang Fan;Federica Di Nardo;Yi-Xuan Feng;Brett W.Fling;Saurabh Garg;Moran Gilat;Martin Gorges;Shu-Leong Ho;Fay B.Horak;Xiao Hu;Xiao-Fei Hu;Biao Huang;Pei-Yu Huang;Ze-Juan Jia;Christina Jones;Jan Kassubek;Lenka Krajcovicova;Ajay Kurani;Jing Li;Qing Li;Ai-Ping Liu;Bo Liu;Hu Liu;Wei-Guo Liu;Renaud Lopes;Yu-Ting Lou;Wei Luo;Tara Madhyastha;Ni-Ni Mao;Grainne McAlonan;Martin J.McKeown;Shirley Pang;Andrea Quattrone;Irena Rektorova;Alessia Sarica;Hui-Fang Shang;James M.Shine;Priyank Shukla;Tomas Slavicek;Xiao-Peng Song;Gioacchino Tedeschi;Alessandro Tessitore;David Vaillancourt;Jian Wang;Jue Wang;Z.Jane Wang;Lu-Qing Wei;Xia Wu;Xiao-Jun Xu;Lei Yan;Jing Yang;Wan-Qun Yang;Nai-Lin Yao;De-Long Zhang;Jiu-Quan Zhang;Min-Ming Zhang;Yan-Ling Zhang;Cai-Hong Zhou;Chao-Gan Yan;Xi-Nian Zuo;Mark Hallett;Tao Wu;Yu-Feng Zang;Center for Cognition and Brain Disorders, the Affiliated Hospital, Hangzhou Normal University;Zhejiang Key Laboratory for Research in Assessment of Cognitive Impairments;National Basic Science Data Center;State Key Laboratory of Cognitive Neuroscience and Learning & McGovern Institute for Brain Research, Beijing Normal University;School of Information and Electronics Technology, Jiamusi University;Neuroscience Program, Central European Institute of Technology, CEITEC, Masaryk University;Department of Applied Physiology and Kinesiology, University of Florida;Univ. Lille, Inserm, CHU Lille, U1172-LilNCog-Lille Neuroscience & Cognition;The Institute for Biomedical Research and Innovation, National Research Council;Department of Radiology, The First Affiliated Hospital of China Medical University;Department of Radiology, Guangdong Provincial Hospital of Chinese Medicine;Department of Medicine, Surgery and Dentistry, Scuola Medica Salernitana, University of Salerno;Department of Advanced Medical and Surgery Sciences, University of Campania ‘‘Luigi Vanvitelli”;Eye Center of the 2nd Affiliated Hospital, Medical College of Zhejiang University;Zhejiang Provincial Key Lab of Ophthalmology;Department of Health and Exercise Science, Colorado State University;Department of Medicine (Neurology) University of British Columbia;Brain and Mind Center, The University of Sydney;Department of Neurology, Ulm University;Division of Neurology, Department of Medicine, Queen Mary Hospital, University of Hong Kong;Department of Neurology, School of Medicine, Oregon Health & Science University;VA Portland Health Care System;Department of Radiology, The Affiliated Brain Hospital with Nanjing Medical University;Department of Radiology, Southwest Hospital, Third Military Medical University;Department of Radiology, Guangdong Academy of Medical Sciences;Department of Radiology, The Second Affiliated Hospital, Zhejiang University School of Medicine;Graduate School of Hebei Medical University;Pacific Parkinson’s Research Centre, University of British Columbia;Department of Neurology, Northwestern University Feinberg School of Medicine;Department of Neurology, Southwest Hospital, Third Military Medical University;College of Information Science and Technology, Beijing Normal University;Department of Electrical and Computer Engineering, University of British Columbia;Department of Neurology, The Affiliated Brain Hospital With Nanjing Medical University;Department of Paediatrics, The Second Affiliated Hospital, Zhejiang University School of Medicine;Department of Neurology, The Second Affiliated Hospital, Zhejiang University School of Medicine;Department of Radiology, University of Washington;South London and Maudsley NHS Foundation Trust;State Key Laboratory for Cognitive Sciences, The University of Hong Kong;Department of Forensic and Neurodevelopmental Science, Institute of Psychiatry, King’s College London;Institute of Neurology, University Magna Graecia of Catanzaro;Neuroscience Center, Department of Medical and Surgical Sciences, Magna Graecia University of Catanzaro;Department of Neurology, West China Hospital, Sichuan University;The Mind Research Network;School of Sports Medicine and Health, Chengdu Sport University;Department of Psychiatry, Queen Mary Hospital, The University of Hong Kong;Human Motor Control Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health;Department of Neurobiology, Neurology and Geriatrics, Xuanwu Hospital of Capital Medical University, Beijing Institute of Geriatrics;Clinical Center for Parkinson’s Disease, Capital Medical University;Beijing Key Laboratory for Parkinson’s Disease, Parkinson Disease Center of Beijing Institute for Brain Disorders;National Clinical Research Center for Geriatric Disorders;

【通讯作者】 左西年;臧玉峰;

【机构】 Center for Cognition and Brain Disorders, the Affiliated Hospital, Hangzhou Normal UniversityZhejiang Key Laboratory for Research in Assessment of Cognitive ImpairmentsNational Basic Science Data CenterState Key Laboratory of Cognitive Neuroscience and Learning & McGovern Institute for Brain Research, Beijing Normal UniversitySchool of Information and Electronics Technology, Jiamusi UniversityNeuroscience Program, Central European Institute of Technology, CEITEC, Masaryk UniversityDepartment of Applied Physiology and Kinesiology, University of FloridaUniv. Lille, Inserm, CHU Lille, U1172-LilNCog-Lille Neuroscience & CognitionThe Institute for Biomedical Research and Innovation, National Research CouncilDepartment of Radiology, The First Affiliated Hospital of China Medical UniversityDepartment of Radiology, Guangdong Provincial Hospital of Chinese MedicineDepartment of Medicine, Surgery and Dentistry, Scuola Medica Salernitana, University of SalernoDepartment of Advanced Medical and Surgery Sciences, University of Campania ‘‘Luigi Vanvitelli”Eye Center of the 2nd Affiliated Hospital, Medical College of Zhejiang UniversityZhejiang Provincial Key Lab of OphthalmologyDepartment of Health and Exercise Science, Colorado State UniversityDepartment of Medicine (Neurology) University of British ColumbiaBrain and Mind Center, The University of SydneyDepartment of Neurology, Ulm UniversityDivision of Neurology, Department of Medicine, Queen Mary Hospital, University of Hong KongDepartment of Neurology, School of Medicine, Oregon Health & Science UniversityVA Portland Health Care SystemDepartment of Radiology, The Affiliated Brain Hospital with Nanjing Medical UniversityDepartment of Radiology, Southwest Hospital, Third Military Medical UniversityDepartment of Radiology, Guangdong Academy of Medical SciencesDepartment of Radiology, The Second Affiliated Hospital, Zhejiang University School of MedicineGraduate School of Hebei Medical UniversityPacific Parkinson’s Research Centre, University of British ColumbiaDepartment of Neurology, Northwestern University Feinberg School of MedicineDepartment of Neurology, Southwest Hospital, Third Military Medical UniversityCollege of Information Science and Technology, Beijing Normal UniversityDepartment of Electrical and Computer Engineering, University of British ColumbiaDepartment of Neurology, The Affiliated Brain Hospital With Nanjing Medical UniversityDepartment of Paediatrics, The Second Affiliated Hospital, Zhejiang University School of MedicineDepartment of Neurology, The Second Affiliated Hospital, Zhejiang University School of MedicineDepartment of Radiology, University of WashingtonSouth London and Maudsley NHS Foundation TrustState Key Laboratory for Cognitive Sciences, The University of Hong KongDepartment of Forensic and Neurodevelopmental Science, Institute of Psychiatry, King’s College LondonInstitute of Neurology, University Magna Graecia of CatanzaroNeuroscience Center, Department of Medical and Surgical Sciences, Magna Graecia University of CatanzaroDepartment of Neurology, West China Hospital, Sichuan UniversityThe Mind Research NetworkSchool of Sports Medicine and Health, Chengdu Sport UniversityDepartment of Psychiatry, Queen Mary Hospital, The University of Hong KongHuman Motor Control Section, National Institute of Neurological Disorders and Stroke, National Institutes of HealthDepartment of Neurobiology, Neurology and Geriatrics, Xuanwu Hospital of Capital Medical University, Beijing Institute of GeriatricsClinical Center for Parkinson’s Disease, Capital Medical UniversityBeijing Key Laboratory for Parkinson’s Disease, Parkinson Disease Center of Beijing Institute for Brain DisordersNational Clinical Research Center for Geriatric Disorders

【摘要】 <正>Thousands of resting state functional magnetic resonance imaging (RS-f MRI) articles have been published on brain disorders. For precise localization of abnormal brain activity, a voxel-level comparison is needed. Because of the large number of voxels in the brain, multiple comparison correction (MCC) must be performed to reduce false positive rates, and a smaller P value (usually including either liberal or stringent MCC) is widely recommended [1].

【基金】 supported by the National Natural Science Foundation of China (81520108016, 81661148045, and 31471084 to Yu-Feng Zang; 81671774 and 81630031 to Chao-Gan Yan; 81571228 to Tao Wu; 61571047 to Xia Wu; 81701664 to Jian Wang, 81471654 to Biao Huang; 81701671 to Wei-Guo Liu; 82001898 to Xi-Ze Jia; 81771820, 81371519 and 81571654 to Wei Luo);Henry G Leong Endowed Professorship in Neurology to Shu-Leong Ho and Shirley YY Pang, BRC for Mental Health at South London and Maudsley NHS Foundation Trust and by the Sackler Institute to Grainne McAlonan, NIH (2R01AG006457 to Fay B. Horak; 1RC4NS073008-01 and P50NS062684 to Tara Madhyastha);NINDS Intramural Research Program to Mark Hallett;Start-up Funds for Leading Talents at Beijing Normal University;National Basic Science Data Center ‘‘Chinese Data-sharing Warehouse for In-vivo Imaging Brain” (NBSDC-DB-15) to Xi-Nian Zuo;Grant NU20-04-00294 of the Agency for Health Research, Czech Republic to Lenka Krajcovicova and Irena Rektorova
  • 【文献出处】 Science Bulletin ,科学通报(英文版) , 编辑部邮箱 ,2021年21期
  • 【分类号】R742.5
  • 【被引频次】5
  • 【下载频次】201
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