【摘要】 目前化疗和放疗仍然是癌症患者的最主要治疗方式。然而,化疗和放疗会对神经系统、肾脏、心肌、肝脏、胃肠道等产生明显的毒副作用,并严重影响患者的生活质量。如何有效减轻化疗、放疗产生的副作用,已成为一个急需解决的重要健康问题。依达拉奉作为一种强效自由基清除剂,是临床治疗急性脑梗死及肌萎缩侧索硬化的常规治疗药物。近年来,研究表明依达拉奉可通过抗氧化、抗炎、抗凋亡等生物学机制,对化疗和放疗引起的神经系统、肾脏、心肌等组织器官的损伤具有良好的保护作用。本文就依达拉奉有效抑制化疗、放疗后产生副作用的研究进展进行简要综述。更多还原

【Abstract】 At present,chemotherapy and radiotherapy are the mainstay of cancer treatment.However,chemotherapy and radiotherapy are associated with various side effects,including neurotoxicity,nephrotoxicity,cardiocytotoxicity,hepatotoxicity,and gastrointestinal toxicity,which severely affect the quality of life of cancer patients.How to effectively reduce the side effects of chemotherapy and radiotherapy has become an important health problem.Edaravone,as a free radical scavenger,is prescribed for the treatment of patients with acute cerebral infarction or amyotrophic lateral sclerosis.Recently,edaravone has been shown to exert protective effects on the injury of nervous system,kidney,and heart caused by chemotherapy and radiotherapy through biological activities,including anti-oxidation,anti-inflammation and anti-apoptosis.This article reviews the research progress of edaravone in inhibiting the side effects of chemotherapy and radiotherapy.更多还原