【摘要】 非酒精性脂肪性肝病(NAFLD)已经逐渐成为引发肝细胞癌(HCC)的重要因素,且NAFLD-HCC与一般肝癌的临床治疗效果存在明显差异,对药物的敏感性有诸多不同。目前NAFLD-HCC的发病机制尚未明确,因此构建临床前的NAFLD-HCC动物模型尤为重要。NAFLD-HCC动物模型的诱导方法多种多样,包括饮食诱导、化学诱导、遗传诱导、饮食结合化学诱导、遗传结合饮食诱导等。越来越多的研究发现,不同方法诱导的NAFLD-HCC动物模型的组织病理学存在一定差异。因此,根据研究目的选择最合适的动物模型,对探讨NAFLD-HCC的发病原因以及后续的新药研发具有重要意义。该文总结已构建的用于NAFLD-HCC临床前研究的鼠模型,以揭示NAFLD-HCC的发生机制,探讨NAFLD-HCC预防或治疗可能的新靶标。更多还原

【Abstract】 Non-alcoholic fatty liver disease (NAFLD) has gradually become an important factor causing hepatocellular carcinoma (HCC),and the clinical treatment effects of NAFLD-HCC and general liver cancer are significantly different,and there are many differences in drug sensitivity.At present,the pathogenesis of NAFLD-HCC is not yet clear.Therefore,it is particularly important to construct pre-clinical animal models of NAFLD-HCC.There are various induction methods for animal models of NAFLD-HCC,including dietary induction,chemical induction,genetic induction,dietary combined with chemical induction,genetic combined with dietary and other induction methods.More and more studies have found that there are certain differences in the histopathological types of animal models of NAFLD-HCC induced by different methods.Therefore,according to the research problem,choosing the most suitable animal model is of great significance for studying the causes of NAFLD-HCC and subsequent development of new drugs.The mouse models established for preclinical studies of the progression of NAFLD-HCC were summarized in this paper to reveal the pathogenesis of NAFLD-HCC,and to explore possible new targets for prevention or treatment of NAFLD-HCC.更多还原