【摘要】 目的探讨对老年抑郁症伴焦虑症状患者实施丁螺环酮联合帕罗西汀治疗的效果。方法便利选取2019年10月—2020年12月该院精神科收治的160例老年抑郁症伴焦虑症状患者,将其按照随机数字表法予以分组,每组80例。对照组实施帕罗西汀治疗,研究组实施丁螺环酮联合帕罗西汀治疗,对比分析两组临床效果。结果治疗前,两组HAMD评分对比差异无统计学意义(P>0.05);对照组治疗2周、4周、8周后HAMD评分分别为(28.89±4.46)分、(26.89±5.61)分、(18.51±5.62)分,研究组治疗2周、4周、8周HAMD评分分别为(17.56±4.10)分、(13.10±3.56)分、(9.81±1.45)分,研究组治疗后HAMD评分低于对照组,差异有统计学意义(t=16.727、18.563、13.407,P<0.001)。治疗前,两组HAMA评分对比差异无统计学意义(P>0.05);对照组治疗2周、4周、8周后HAMA评分分别为(20.89±4.56)分、(19.89±5.56)分、(18.08±3.10)分,研究组治疗2周、4周、8周后HAMA评分分别为(18.23±4.78)分、(16.10±3.36)分、(7.77±2.78)分,研究组治疗后HAMA评分低于对照组,差异有统计学意义(t=14.432、5.218、22.146,P<0.001)。从副反应量表(TESS)评分分析,治疗2周、4周、8周两组评分对比差异无统计学意义(P>0.05)。结论对于老年抑郁症伴焦虑症状患者而言,丁螺环酮联合帕罗西汀治疗效果更佳,可使抑郁和焦虑症状得到有效改善,而且安全性良好,临床价值显著。更多还原

【Abstract】 Objective To odiscuss the effect of buspirone combined with paroxetine in the treatment of senile depression with anxiety symptoms. Methods A total of 160 elderly patients with depression and anxiety symptoms admitted to the psychiatric department of the hospital from October 2019 to December 2020 were convenient selected and divided into groups according to random number table method, with 80 cases in each group. The control group was treated with paroxetine, and the study group was treated with buspirone combined with paroxetine. The clinical effects of the two groups were compared and analyzed. Results Before treatment, there was no statistically significant difference in HAMD score between the two groups(P>0.05). The HAMD scores of the control group were(28.89±4.46) points,(26.89±5.61) points,(18.51±5.62) points after 2, 4 and 8 weeks of treatment, respectively. The HAMD scores of the study group were(17.56±4.10) points,(13.10±3.56) points and(9.81±1.45) points after 2, 4 and 8 weeks of treatment, respectively. The HAMD scores of the study group were lower than those of the control group, and the differences were statistically significant(t=16.727,18.563, 13.407, P< 0.001). Before treatment, there was no statistically significant difference in HAMA scores between the two groups(P>0.05). HAMA scores of control group were(20.89±4.56) points,(19.89±5.56) points,(18.08±3.10) points after2, 4 and 8 weeks of treatment, respectively. HAMA scores in the study group were(18.23±4.78) points,(16.10±3.36) points and(7.77±2.78) points after 2, 4 and 8 weeks of treatment, respectively. HAMA scores in the study group were lower than those in the control group, and the differences were statistically significant(t=14.432, 5.218, 22.146, P<0.001). According to the analysis of TESS score, there was no statistically significant difference between the two groups at 2, 4 and 8 weeks of treatment(P >0.05). Conclusion Buspirone combined with paroxetine is more effective in the treatment of senile depression with anxiety symptoms, which can effectively improve the symptoms of depression and anxiety, with good safety and significant clinical value.更多还原