【摘要】 目的分析免疫指标与系统性红斑狼疮疾病严重程度的相关性。方法方便选择2019年1月—2020年12月该院确诊并收治的系统性红斑狼疮患者108例,采用SLEDAI积分表评定系统性红斑狼疮患者的严重程度,分析不同严重程度的系统性红斑狼疮患者免疫指标的情况,分析免疫指标与系统性红斑狼疮疾病严重程度的相关性。结果108例系统性红斑狼疮患者中,基本无活动者占2.78%;轻度活动者占25.93%;中度活动者占49.07%;重度活动者占22.22%。不同严重程度系统性红斑狼疮患者免疫指标水平比较,差异有统计学意义(P<0.05),且IgA、IgM、IgG的水平增高,而C3、C4水平降低。不同严重程度系统性红斑狼疮患者抗ds-DNA(P=0.049)、抗体ANAS(P=0.028)和ENA(P=0.004)阳性检出率比较,差异有统计学意义(P<0.05),随着严重程度增加,阳性率增加。采用线性相关分析,发现系统性红斑狼疮患者严重程度与IgA、IgM、IgG成正相关,且与IgA存在显著性相关,与IgM、IgG存在高度相关;与C3、C4成负相关,且呈现高度负相关;与ds-DNA(+)呈现高度正相关,与ANAS(+)和ENA呈现一般正相关。结论为系统性红斑狼疮患者选择适宜的免疫指标,可评估患者活动严重程度,为临床诊断和治疗提供依据。更多还原

【Abstract】 Objective To analyze the correlation between immune indexes and the severity of systemic lupus erythematosus.Methods 108 patients with systemic lupus erythematosus who were diagnosed and treated in the hospital from January 2019 to December 2020 were conveniently selected. The SLEDAI score table was used to evaluate the severity of systemic lupus erythematosus patients. The immune indexes of patients with different severity of systemic lupus erythematosus were analyzed, and the correlation between immune indexes and disease severity of systemic lupus erythematosus was analyzed.Results Among 108 patients with systemic lupus erythematosus, 2.78% were basically inactive; 25.93% were mildly active;49.07% were moderately active; 22.22% were severely active, there was a statistically significant difference in the levels of immune indicators in patients with systemic lupus erythematosus of different severity(P<0.05), and the levels of IgA, IgM,and IgG increased, while the levels of C3 and C4 decreased. Comparison of the positive detection rates of anti-ds-DNA(P=0.049), ANAS(P=0.028) and ENA(P=0.004) antibodies in patients with different severity of systemic lupus erythematosus,the difference was statistically significant(P <0.05). As the severity increased, the positive rate increased. Using linear correlation analysis, it was found that the severity of systemic lupus erythematosus patients was positively correlated with IgA, IgM, and IgG, and was significantly correlated with IgA, and was highly correlated with IgM and IgG; it was negatively correlated with C3 and C4, and was highly negatively correlated; it was highly positively correlated with ds-DNA(+), and was generally positively correlated with ANAS(+) and ENA. Conclusion The selection of appropriate immune indicators in patients with systemic lupus erythematosus can evaluate the severity of patients’ activity and provide basis for clinical diagnosis and treatment.更多还原