【摘要】 微波辅助下,以稻壳灰负载氯磺酸为固体酸催化剂,以芳香醛、丙二腈和二甲基环己二酮为原料进行"一锅法"缩合反应,所得到的中间体2-氨基-3-氰基苯并吡喃不需分离和纯化,直接加入乙酸酐继续缩合成环制备得到吡喃并[2,3-d]嘧啶衍生物(2a～2g),合成收率为83～92%,其结构经IR、~1HNMR、MS(EI)和元素分析等测试技术加以确证。初步的活性测试结果表明,部分目标化合物对大肠杆菌、枯草杆菌和金黄色葡萄球菌都有不同程度的抑制作用。更多还原

【Abstract】 A series of pyrano[2,3-d]pyrimidine derivatives(2 a～2 g)via the condensation reaction between acetic anhydride and 2-amino-3-cyano-4H-pyran derivatives were reported.The one-pot three-component condensation procedure was carried out by arylaldehydes with malononitrile and 5,5-dimethylcyclohexane-1,3-dione under microwave irradiation in the presence of rice husk ash supported chlorosulfonic acid and without purification, and with 83～92% yield respectively.The structures of the corresponding products were confirmed by IR,~1HNMR,MS(EI)and elemental analysis.Preliminary bioassay results showed that some of them had certain antibacterial activities against Escherichia Coli, Bacillus Subtilis and Staphylococcus Aureus.更多还原