【摘要】 1,1′-联萘-2,2′-双二苯膦与金属配位化合物(BINAP-M)作为最重要和著名的手性催化剂之一,过去的几十年中在工业和基础理论研究中受到广泛关注。虽然BINAP-M作为均相手性催化剂具有活性高和选择性好的特点,但存在价格昂贵、应用成本较高和难以回收利用等局限性,特别是催化剂残留在合成产物中,如药品中,限制了其在工业上的大规模应用。因此,寻求既能保持高催化活性,又能方便回收和循环应用的BINAP-M类催化剂成为重要研究课题。本文总结了近年来可回收BINAP-M催化剂研究进展,重点介绍了吸附负载型与共价负载型BINAP-M催化剂在可回收领域的研究成果,分析讨论了不同类型可回收的负载型BINAP-M催化剂的优缺点。在此基础上,本文还介绍了一种具有"柔性桥链"结构的共价负载BINAP-M催化剂,并分析了其在"拟均相"催化反应中的应用前景,为负载型催化剂的设计与制备提供了新的研究思路。更多还原

【Abstract】 As one of the most important and well-known chiral catalysts, 1,1′-binapthyl-2,2′-bisdiphenylphosphine metal complexes(BINAP-M) have been widely concerned in industry and basic theoretical research in the past few decades. Although BINAP-M as a homogeneous chiral catalyst has the characteristics of high activity and good selectivity, it also has the limitations of high price, high application cost and difficult to recycle, especially the catalyst residues in synthesis products such as pharmaceutical products, which limits its large-scale application in industry. Therefore, it has become an important research topic to search for BINAP-M catalysts which can not only keep high catalytic activity, but also be easy to recover and recycle. In this paper, the research progress of recyclable BINAP-M catalysts in recent years is summarized. The research results of adsorption-supported and covalently-supported BINAP-M catalysts in the field of recyclability are mainly introduced. The advantages and disadvantages of different types of recyclable BINAP-M catalysts are analyzed and discussed. On this basis, a covalently-supported BINAP-M catalyst with “flexible bridge chain” structure is also introduced, and its application prospect in “quasi-homogeneous” catalytic reaction is analyzed, which provides a new research idea for the design and preparation of supported catalyst.更多还原