【摘要】 临床研究证实雷奈酸锶可以通过改善骨形成同时减少骨吸收以抑制骨质疏松症。这些作用部分是通过锶对骨代谢的影响来介导的,微量元素锶能够促进成骨和血管生成。目前,在骨科相关领域对掺锶复合材料的研究日益增多。本文主要综述了锶对骨组织的主要作用机制,以及与骨之间的相互作用,亦着重介绍了不同锶掺杂生物材料在局部骨组织修复中的应用,尤其是在骨质疏松性骨再生中的应用,以期为锶在骨修复中的进一步应用提供理论依据。更多还原

【Abstract】 Clinical studies have confirmed that strontium ranelate can inhibit osteoporosis by improving bone formation and reducing bone resorption. These effects are partly mediated by the effect of strontium on bone metabolism. Trace element strontium can promote osteogenesis as well as angiogenesis. To date, the research on strontium-doped composites is increasing in orthopaedic related field. The current article mainly reviews the main action mechanisms of strontium on bone tissue, including the validated and potential mechanisms, as well as the detailed biological interaction between strontium and bone. This article also focuses on different strontium-doped biomaterials applied in the local bone tissue repair, especially for the osteoporotic bone regeneration. We hope that this review would shed light on the rationale for further application of strontium in bone repair.更多还原