【摘要】 空气细颗粒物(PM_2.5)污染已成为影响人体健康的重要因素,其健康效应及致炎症机制已经受到人们的广泛关注。简述了PM_2.5国内外污染现状,从PM_2.5的质量浓度和组成成分2个方面系统地阐述了其对人体健康的危害,并重点从介导信号通路和介导细胞自噬2个方面对PM_2.5导致机体炎症反应的毒性机制进行了总结和讨论,为后续研究和控制PM_2.5对机体健康的危害提供科学参考。更多还原

【Abstract】 Air fine particulate matter( PM_2.5) pollution has become an important factor affecting human health,and its health effects and inflammatory mechanisms have been widely concerned by people. This article briefly describes the pollution status at home and abroad. The harm to human health was systematically expounded in terms of the chemical components of PM_2.5. In addition,the toxic mechanism of PM_2.5 causing body inflammation was summarized and discussed from two aspects of signal pathway and autophagy,so as to provide the corresponding scientific reference basis for the follow-up research and control of the harm of atmospheric particulate matter to body health.更多还原