【摘要】 目的比较不同级别乳腺浸润性导管癌临床、FFDM征象及免疫组化指标差异,为临床预测组织学分级和预后评估提供科学依据。方法回顾性收集138例经手术或穿刺病理证实为低级别(Ⅰ级+Ⅱ级)和高级别(Ⅲ级)乳腺浸润性导管癌患者的临床、FFDM征象及免疫组化资料,包括年龄、病灶形态、有无毛刺、有无恶性钙化、ER(-/+)、PR(-/+)、C-erbB-2(-/+)。比较低级别与高级别乳腺浸润性导管癌患者的临床资料、FFDM征象及免疫组化指标。结果低级别浸润性导管癌68例,年龄31～78岁,平均年龄(52.26±9.46)岁;病灶形态:圆形2例,卵圆形7例,不规则形59例;无毛刺24例,有毛刺44例;有恶性钙化42例,无恶性钙化26例;免疫组化指标:ER(+)59例,ER(-)9例;PR(+)56例,PR(-)12例;C-erbB-2(+)57例,C-erbB-2(-)11例。高级别浸润性导管癌70例,年龄26～86岁,平均年龄(51.16±11.15)岁;病灶形态:圆形1例,卵圆形15例,不规则形54例;无毛刺39例,有毛刺31例;有恶性钙化46例,无恶性钙化24例;免疫组化指标:ER(+)31例,ER(-)39例;PR(+)31例,PR(-)39例;C-erbB-2(+)58例,C-erbB-2(-)12例。低级别与高级别两组病例在肿块边缘有无毛刺、ER(-/+)、PR(-/+)方面比较差异有统计学意义(P<0.05)。低级别与高级别两组病例在年龄、病灶形态、有无恶性钙化、C-erbB-2(-/+)方面比较差异无统计学意义(P>0.05)。结论低级别与高级别乳腺浸润性导管癌在病灶边缘有无毛刺、ER(-/+)、PR(-/+)之间存在差异,可以为临床预测组织学分级和预后评估提供有价值的科学依据。更多还原

【Abstract】 Objective To compare clinical, FFDM imaging features, and immunohistochemical indexes of different grades breast invasive ductal carcinoma, and to provide scientific basis for clinical prediction of histological grading and prognosis evaluation. Methods The clinical, FFDM imaging features, and immunohistochemical datas of 138 patients with low grade(grade Ⅰ+Ⅱ) and high grade(grade Ⅲ) breast invasive ductal carcinoma confirmed by operation or biopsy were retrospectively collected, including age, lesions shape, the presence or absence of burr and calcification, ER(-/+), PR(-/+), C-erbB-2(-/+). Comparing clinical, FFDM imaging features, and immunohistochemical indexes of low grade and high grade breast invasive ductal carcinoma. Results 68 cases of low grade, aged 31-78 years old, average(52.26±9.46); lesions shape: round 2 cases, oval 7 cases, irregular 59 cases, no burr 24 cases, burr 44 cases, calcification 42 cases, no calcification 26 cases; immunohistochemistry indexes: ER(+) 59 cases, ER(-) 9 cases, PR(+) 56 cases, PR(-) 12 cases, C-erbB-2(+) 57 cases, C-erbB-2(-) 11 cases. 70 cases of high grade, aged 26-86 years old,average(51.16±11.15); lesions shape: round 1 case, oval 15 cases, irregular 54 cases, no burr 39 cases, burr 31 cases, calcification 46 cases, no calcification 24 cases; immunohistochemistry indexes: ER(+) 31 cases, ER(-) 39 cases, PR(+) 31 cases, PR(-) 39 cases, C-erbB-2(+) 58 cases, C-erbB-2(-) 12 cases. There were significant differences in the presence or absence of burr, ER(-/+), PR(-/+) between low grade and high grade breast invasive ductal carcinoma(P<0.05). There were no significant differences in age, lesions shape, the presence or absence of calcification and c-erbB-2(-/+) between the two groups. Conclusion Low-grade and high-grade breast invasive ductal carcinoma have difference in the presence or absence of burr, ER(-/+), PR(-/+), which can provide valuable scientific basis for clinical prediction of histological grading and prognosis evaluation.更多还原