【摘要】 神经内分泌肿瘤是起源于分布全身的神经内分泌细胞的少见肿瘤,2010年WHO将消化道神经内分泌肿瘤分为三类:神经内分泌瘤、神经内分泌癌、混合性腺神经内分泌癌,其中混合性腺神经内分泌癌是罕见、恶性程度极高的一类,病理诊断是"金标准",免疫组化是病理诊断的重要补充及分级标准。本研究回顾性分析一例极其罕见的发生在胃底贲门的混合鳞癌成分的神经内分泌癌,并复习相关文献,以期提高对神经内分泌肿瘤的认识。更多还原

【Abstract】 Neuroendocrine neoplasm(NEN)are rare tumors originating from neuroendocrine cells distributed throughout the body. In 2010, WHO classified gastrointestinal NEN into three categories: neuroendocrine tumor(NET), neuroendocrine carcinoma(NEC)and mixed adenoneuroendocrine carcinoma(MANEC), of which MANEC is a rare type with extremely high malignancy. Pathological diagnosis is the gold standard, and immunohistochemistry is a crucial supplement and grading standard. This article retrospectively analyzed a rare case of NEC with mixed squamous cell carcinoma in the fundus and cardia of the stomach, and relevant literature was reviewed to improve the understanding of NEN.更多还原