【摘要】 目的:观察栀黄止痛散外敷治疗急性痛风性关节炎患者的临床疗效,并观察其对患者血清炎性因子水平的影响。方法:60例急性痛风性关节炎患者分为栀黄止痛散组和安康信组各30例。安康信组给予口服安康信,栀黄止痛散组在对照组治疗基础上给予外敷栀黄止痛散,两组均治疗两周。比较两组患者治疗前,治疗第3天、第7天、第14天的视觉模拟评分(visual analogue scale,VAS);比较两组患者治疗前、治疗第7天、第14天血尿酸(uric acid,UA)、C-反应蛋白(C-reactive protein,CRP)、红细胞沉降率(erythrocyte sedimentation rate,ESR)、白细胞介素-6(interleukin-6,IL-6)、IL-8、IL-1β和肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)水平,同时比较两组患者临床疗效。结果:栀黄止痛散组有效率为96.6%,安康信组有效率为80.0%,两组有效率比较,差异有统计学意义(P<0.05);治疗第3天,栀黄止痛散组的VAS低于安康信组(P<0.05);治疗第7天,栀黄止痛散组UA、CRP、ESR、IL-6、IL-8、TNF-α和IL-1β均低于安康信组(P<0.05);治疗第14天,栀黄止痛散组UA、ESR、CRP水平低于安康信组(P<0.05)。两组治疗后各时间点以上指标与治疗前比较,差异均有统计学意义(P<0.05)。结论:栀黄止痛散外敷治疗急性痛风性关节炎疗效显著,可显著降低患者血清炎性因子、ESR、CRP、UA水平,显著改善患者临床症状。更多还原

【Abstract】 Objective:To observe the clinical efficacy of Zhihuang Zhitong Powder in the treatment of patients with acute gouty arthritis and its effect on serum inflammatory factors.Methods:60 patients with acute gouty arthritis were divided into Zhihuang Zhitong Powder group and Ankangxin group,30 cases in each group.Ankangxin group was given Ankangxin orally,while Zhihuang Zhitong powder group was given external application of Zhihuang Zhitong Powder on the basis of control group.Both groups were treated for two weeks.The visual analogue scale(VAS) of the two groups before treatment and on the 3 rd,7 th and 14 th day after treatment were compared;blood uric acid(UA),C-reactive protein(CRP),erythrocyte sedimentation rate(ESR),interleukin-6(IL-6),IL-8,IL-1β and tumor necrosis factor-α(TNF-α) were compared between the two groups before treatment and on the 7 th and 14 th day after treatment-α.Meanwhile,the clinical efficacy of the two groups was compared.Results:The effective rate of Zhihuang Zhitong Powder group was 96.6%,and that of Ankangxin group was 80.0%,and the difference was statistically significant(P<0.05);after 3 days of treatment,the VAS of Zhihuang Zhitong Powder group was lower than that of Ankangxin group(P<0.05);after 7 days of treatment,UA,CRP,ESR,IL-6,IL-8,TNF-α and IL-1β of Zhihuang Zhitong Powder group were lower than those of Ankangxin group(P<0.05);on the 14 th day after treatment,UA level in Zhihuang Zhitong Powder group was lower than that in Ankangxin group(P<0.05).There were significant differences in the above indexes at each time point after treatment between the two groups(P<0.05).Conclusion:Zhihuang Zhitong Powder is effective in the treatment of acute gouty arthritis,which can significantly reduce the levels of serum inflammatory factors,ESR,CRP and UA,and significantly improve the clinical symptoms.更多还原