【摘要】 目的:研究化瘀消癥方在子宫腺肌病合并不孕患者Gn RH-a治疗后窗口期应用的临床疗效。方法:将60例子宫腺肌病合并不孕Gn RH-a治疗后窗口期的患者随机分为治疗组及对照组,各30例。对照组予尿促卵泡素+绒促性素+来曲唑治疗,治疗组在对照组的基础上加化瘀消癥方。结果:两组患者治疗前后子宫体积、内膜厚度、子宫动脉搏动指数(PI)、阻力指数(RI)、收缩期血流速度峰值(PSV)比较,差异均有统计学意义(P<0.05);血清CA125值比较,差异无统计学意义(P>0.05)。治疗后组间比较,治疗组患者子宫体积、内膜厚度、PI、RI、PSV均优于对照组,差异均有统计学意义(P<0.05),血清CA125值比较,差异无统计学意义(P>0.05)。治疗组妊娠率为60.00%(18/30),高于对照组的33.33%(10/30),差异有统计学意义(P<0.05)。结论:子宫腺肌病合并不孕Gn RH-a治疗后窗口期联合化瘀消癥方可改善子宫动脉血流情况,增加内膜厚度,提高宫内自然妊娠率。更多还原

【Abstract】 Objective: To study the clinical effect of Huayu Xiaozheng Prescription in the treatment of adenomyosis with infertility in the window period after GnRH-a treatment. Methods: Totally 60 patients were randomly divided into treatment and control groups. Patients were given urofollicle stimulating hormone +chorionic gonadotropin + letrozole in control group. Patients in treatment group were treated by Huyu Xiaozheng Prescription on the basis of the control group. Results: There were significant differences in uterine volume,endometrial thickness, uterine artery pulsation index(PI), resistance index(RI) and peak systolic blood flow velocity(PSV) before and after treatment in the two groups(P<0.05). There was no significant difference in serum CA125 before and after treatment(P>0.05). After treatment, the treatment group showed better uterine volume,endometrial thickness, PI, RI and PSV than the control group, and the difference was statistically significant(P<0.05). There was no significant difference in serum CA125 between the two groups(P>0.05). The pregnancy rate was 60.00%(18/30) in the treatment group and 33.33%(10/30) in control group. The treatment group showed higher pregnancy rate than control group(P <0.05). Conclusion: Huayu Xiaozheng Prescription can improve the blood flow of uterine artery, increase the thickness of endometrium, and enhance the rate of intrauterine natural pregnancy in the window period after GnRH-a treatment for adenomyosis with infertility.更多还原